Cincinnati Children's Hospital to Study Migraine Medications in Child Migraineurs

Earlier this fall we got some exciting news about research of migraine in children and adolescents.

Migraine among children and adolescents has been largely ignored for many years. Many people mistakenly believe migraine only impacts adults and that it is impossible for a child to have a migraine attack.The truth is that somewhere between 5 to 10% of children experience migraine and the number is higher among adolescents, for whom puberty and fluctuating hormones can cause issues.

Most medications are not FDA approved for children and not only are there few medication to treat their unrelenting attacks, there are no FDA approved medications for preventing them. Cincinnati Children's Hospital Medical Center and the federal government are working to change that.

Cincinnati Children's Hospital has been awarded a $12 million federal grant from the National Institutes of Health to conduct a clinical trial to determine which migraine medications are most effective for preventing attacks among children and adolescents.

The study will compare two medications commonly prescribed for migraine prevention in adults, Amitriptyline and Topamirate. The five-year study will examine 675 between the ages of 8 and 17 to determine the effectiveness of the two medications and track their side effects. Topamirate has been known to cause strange side effects in adults, such as difficulty concentrating, dizziness, etc., nausea and numbness in the hands and feet.

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