Nationwide Recall of Toradol

Toradol, also known as Ketorolac, is a non-steroidal anti-inflammatory drug (NSAID). It is used on a short term basis to treat severe pain. It can be taken as a pill, used as an injection or given through an IV. It is often used to reduce fever, pain and swelling. For Migraineurs, Toradol is used in the emergency room along with a cocktail of other medications to try to break a bad cycle of Migraines. Occasionally it is prescribed to a patient to use at home.

I personally use Toradol at home when I’ve had days of relentless Migraines. It’s usually a last resort before I go to the ER. I take it as an injection. Recently I went to fill a prescription of Toradol and was told that the manufacturer was not currently distributing this drug and there wasn’t a date set as to when it would be available. Good thing I didn’t need it right away, I was just trying to stockpile as much as I could.

According to a press release, particulate matter was found in vials of Toradol. Particulate matter could mean that a hard substance was found floating in the liquid vials, in this case it was calcium-ketorolac crystals. Likely this is caused by improper packaging or storage. Affected vials were distributed between Feb 2013 and Dec 2014.


While not life-threatening if the medication was used, it could cause inflammation at the injection site, delayed effects of the drug or allergic reaction. I called the manufacturer, Hospira, to find out when the drug is expected to become available again. I was told that because of this issue, Hospira basically swept the drug off the shelves and is currently working to replace the inventory. Within the past two weeks, Hospira began to distribute new vials of Toradol to hospital and wholesalers, however it can take time for the market to become saturated again with a new supply.

Upon further investigation, Hospira has recalled their drugs 20 times in the past 6 months. Drugs such as lidocaine, heparin, propofol, sodium chloride, dextrose and fentanyl. Reasons for the recalls range from particulate matter, leaking packages, mislabeling, cracked glass or vials, mold and improper temperature storage. In February 2015, Pfizer Pharmaceutical announced that it is purchasing Hospira. Hopefully this merger will improve the manufacturing standards of these drugs.

To read Hospira’s press release about the Toradol recall and to find out if you are in possession of any affected vials, go to: http://www.fda.gov/Safety/Recalls/ucm433857.htm

I also found that Sagent Pharmaceuticals, which also produces Toradol, recalled three lots of the medication in October 2014. This recall was due to incorrect labeling of the expiration date. For more information about this recall, visit: http://investor.sagentpharma.com/releasedetail.cfm?releaseid=874502

If you want to know if a medication you are on has been recalled, the Food and Drug Administration compiles an updated list. If you ever question that a drug you have received is tainted, report your concerns to the manufacturer as well as the FDA. http://www.fda.gov/Safety/Recalls/

This article represents the opinions, thoughts, and experiences of the author; none of this content has been paid for by any advertiser. The Migraine.com team does not recommend or endorse any products or treatments discussed herein. Learn more about how we maintain editorial integrity here.

Comments

View Comments (8)
  • Katie M. Golden moderator author
    3 years ago

    Just thought I’d update this topic. The link below shows that the FDA is recalling some Class I drugs from 2013 to present. At the top is Hospira. As discussed above for Migraine patients, their product Toradol has had some particulate matter in it. This can cause bruising, infection or itching of the injection site.
    http://www.fiercepharmamanufacturing.com/special-reports/top-class-i-drug-recallers

  • MPgirl33
    4 years ago

    I’m so glad I didn’t go to the ER Wednesday. That’s part of my cocktail.

  • Katie M. Golden moderator author
    4 years ago

    @Gabbymassey,
    Yes, I add injectible DHE to the mix when trying to get out of the Migraine cycle along with Toradol. I’ll do that for a day or two, praying it will work. Sometimes it does and other times I throw in the towel and go to the ER. They usually give me Toradol and DHE and via IV along with magnesium, phenergan, a steroid, and sometimes dilaudid if none of that helps.

    I also alternate between each thigh. It can get very sore easily and I think I’ve developed some scar tissue from it. I can’t find any info on other sites that are good for injections. For some reason, I remember my doc telling me that the arm was not good and to stick with the thighs. I’ll try to remember to ask next time I’m there.

  • Katie M. Golden moderator author
    4 years ago

    In response to a member’s concern about this article, I want to share the following information. I commented that Hospira has had 20 recalled medications in the last 6 months, a fact from the company’s website http://hospira.com/en/support_center/customer_communications/solutions_injectables/index
    I made a comment suggesting that Pfizer’s recent purchase of Hospira should improve Hospira’s manufacturing process. While not fully explained in the article, this comment was made based on facts that I uncovered during hours of research for this article.
    Since Sept 1, 2014, Hospira has had 20 of their drugs either voluntarily recalled or required by the FDA. Again, reasons varied from particulate matter, leaking packages, mislabeling, cracked glass or vials, mold and improper temperature storage. Actually, since I wrote the article yesterday, 3 additional Hospira drugs have been recalled.
    In contrast, Pfizer, has only had ONE of their prescription drugs recalled in the same timeframe, Effexor. I have contacted Pfizer to confirm this information. Pfizer produces close to one thousand drugs while Hospira only produces 227 medications. I concluded that based on this information, Pfizer has a better track record of safety in their manufacturing process than Hospira has in the recent past.
    Additionally, in researching other drugs recalled since Sept 1, 2014, twelve pharmaceutical companies had recalled ONE drug. There was one company that recalled TWO drugs and an additional company had recalled THREE drugs. In the recent past, no other drug company has come close to needing to recall 20 of their medications as Hospira has.
    The Wall Street Journal reported on Feb 12, 2015 that Hospira settled a $2.6 million lawsuit that was brought against them by their own shareholders! The lawsuit was filed against “certain officers and directors in 2011, accusing them of breaching their fiduciary duties by failing to correct known manufacturing deficiencies, and by misleading investors about the problems.” http://www.wsj.com/articles/painkiller-in-short-supply-following-hospira-recall-1423774295
    I stand by my statement, but should have included the above information in the article. It was originally written to make Migraineurs aware of the Toradol drug shortage, but I quickly learned there was a bigger issue here and felt it was worth mentioning. I’m a blogger, not a journalist, but I work hard to never make off-hand remarks that aren’t based in fact.
    -Katie

  • Gabymassey
    4 years ago

    Thank you so much for doing this – it sent me straight to my drawer to check the lot number – luckily my number wasn’t on the list. I have a few questions for you – first, to break a migraine cycle, do you use JUST the toradol or do you add it to DHE45 (as I do)? How many shots/doses do you find necessary to break a cycle? And where do you inject? I use the front of my thighs and alternate, as I was originally told to, but which causes fun bruising and frequently a tender lump too.I’ve been wondering about whether to do it in a pinch of stomach?

  • 2MuchPain
    4 years ago

    I live in Calif and was told the injectable Toradol would be available again at the end of March beginning of April. I so hope that’s true, I rely on it for my chronic migraines. I’ve been down with a migraine for 2 days now and the pain medication in pill form just causes vomiting. Going to the ER here takes hours ( 5-12 ) and I can’t get anyone to confirm they even have Toradol in stock there.
    I’ll take advice from this article and stock pill next time !

  • zippy36
    4 years ago

    Are you speaking of the injection ?? I have tablets in case of emergency also but have not had to use them yet.

  • 2MuchPain
    4 years ago

    Yes..just the injectable form.

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