Gralise and Chronic Migraine

I have dealt with chronic migraine for so many years. Due to this, I have an extensive history of medications and treatments that I have tried to help with my migraines.

This ends up putting me in a ‘problem child’ classification with most medical professionals because it becomes hard for them to come up with medications to suggest that I have not tried at some point in my migraine journey.

What is Gralise (gabapentin)?

Gralise is one of the newer medications released in the GABA analogue medication class. GABA is abbreviated for gabapentin, which is a class of medications designed to primarily treat nerve pain in adults.

The class of medications contains other prescriptions that I have tried before without having any success. So, if we are being completely honest, I was not too sure how I felt about this medication and its potential ability to help me with my chronic migraine pain.

My first 30 days

On one of my attempts to see a pain management specialist, the doctor discussed Gralise with me. They informed me that there was a common 30-day trial or sampler pack, which he could give me to try out. Then true to the other pain management doctors that I have seen, told me that if it did help me I could talk to another doctor about continuing the Gralise.

Despite his forwardness about not wanting to see me again, I started with this 30-day sample pack. Before I finished the 30-day sample pack, I already began to see some benefits from the Gralise. The medication started by lowering my daily pain level and it also increased my ability to sleep at night. Sleep is extra important for those of us with chronic migraine because lack of sleep or good enough sleep can easily cause another migraine or a worse migraine.

After several months on Gralise

A major benefit to Gralise over the other versions of gabapentin medications is that it is taken once a day, in the evening. The other gabapentin medications are typically taken three times a day or so and have been known to cause drowsiness or fatigue during the day, especially when on higher doses.

I do still get migraines. I am not saying that this medication is a ‘cure.’ Honestly, I know by the way my migraine feels if it is a regular ‘for me’ migraine or if the migraine is because I have missed a dose of my Gralise medication. That being said, if you choose to try Gralise and you decide to stop taking it, I suggest tapering off the medication and not stopping cold turkey. If you do not taper off, you could have withdrawal.

Hopefully, this review provides somebody with a new medication option to try for their chronic migraine pain. Even if the other GABA analogue medications were unsuccessful.

Have you tried any of the GABA analogue medications for your chronic migraine treatment? If so, what was your experience on them? Have you tried Gralise specifically as well?


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This article represents the opinions, thoughts, and experiences of the author; none of this content has been paid for by any advertiser. The team does not recommend or endorse any products or treatments discussed herein. Learn more about how we maintain editorial integrity here.

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