Impact on quality of life SHARE RATE★★★★★ Participants noted that migraine has had an impact on their relationships and careers, including job loss and divorce. Next Sign up for emails from Migraine.com: Thanks! You're all set! Good news - you're already subscribed! Need help? Let us know at contact@Migraine.com. Something's not right... Try again or let us know at contact@Migraine.com.