Treatment Approaches SHARE RATE★★★★★ A vast majority of migraine sufferers have tried prescription medications (90%) and OTC pain medications (79.9%) in addition to other forms of treatments. Next Sign up for emails from Migraine.com: Thanks! You're all set! Good news - you're already subscribed! Need help? Let us know at contact@Migraine.com. Something's not right... Try again or let us know at contact@Migraine.com.