Amerge Drug Interactions

Amerge Drug Interactions Introduction

Amerge may interact with other medicines. It is extremely important for you to tell your doctor about all the medicines you are currently taking, including your over-the-counter (non-prescription) medicines. The migraine journal can help you keep a list of all of your medicines. It is also important that you tell your doctor if you are taking any dietary supplements such as herbs or vitamins. Your doctor can best help you avoid any unpleasant side effects if he or she knows about everything that you are taking.


Amerge Drug Interactions with Other Migraine Medicines

Amerge should not be used within 24 hours after another drug containing triptan (found in some similar migraine medications), ergotamine (found in some migraine and cluster headache medications), or ergot-type medication like Migranal (dihydroergotamine injection), D.H.E. 45 (dihydroergotamine nasal spray) or methysergide. Taking these drugs together could cause your blood vessels to constrict too much. If you are already taking any migraine medication, make sure you tell your doctor before beginning to take Amerge.

Amerge Drug Interactions with Antidepressants

According to the prescribing information, interactions between Amerge and MAO inhibitors (monoamine oxidase inhibitors — a class of antidepressants) are not likely to occur.

However, taking Amerge with two other classes of antidepressants – SSRIs (selective serotonin reuptake inhibitors) or SNRIs (serotonin-norepinephrine reuptake inhibitors) — may cause a potentially life-threatening reaction called serotonin syndrome. Serotonin syndrome symptoms may include changes in your thinking, behavior, or level of alertness (e.g., agitation, hallucinations, coma). It can also cause changes in your heart rate, blood pressure, or body temperature (e.g. fast heart beat, high or low blood pressure, or fever), changes in your muscles and/or nervous system (e.g., sensitive reflexes or lack of coordination), and/or nausea, vomiting, and/or diarrhea.

Before using Amerge, tell your doctor if you are also taking an antidepressant such as:

  • Celexa (citalopram)
  • Cymbalta (duloxetine)
  • Effexor (venlafaxine)
  • Lexapro (escitalopram)
  • Luvox (fluvoxamine)
  • Paxil (paroxetine)
  • Prozac (fluoxetine)
  • Sarafem (fluoxetine)
  • Zoloft (sertraline)

Written & reviewed by: Lisa Erwin R.Ph. CGP | Last review date: Dec 2010. Click the References Link below for a complete list of references.

Written & reviewed by: Lisa Erwin R.Ph. CGP | Last review date: Dec 2010.
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