Amerge Special Warnings

Amerge Special Warnings Overview

  • Amerge and Overuse
  • Amerge and Blood Pressure
  • Amerge and Heart Disease
  • Amerge and Kidney/Liver Problems


Amerge and Overuse

Using Amerge 2 or more days a week for more than 3 months can cause medication-overuse headache, a dull or migraine-like headache that is present at least 15 days per month. You can prevent medication-overuse headache by not using Amerge as often (per attack, per week, and per month) and starting preventive treatment when necessary. Talk with your doctor about whether or not you would benefit from trying a medicine that prevents migraines. If you continue to experience overuse headaches, you may need to stop taking Amerge entirely.

By keeping a migraine journal of what doses you are taking when you experience a migraine, you can be prepared to discuss if you might be experiencing overuse headaches. Be sure to share your headache log with your doctor at your next appointment.


Amerge and Blood Pressure

Amerge should not be taken by people with uncontrolled high blood pressure. Amerge has been reported to raise blood pressure on rare occasions in patients with and without high blood pressure.


What is your blood pressure? Keeping a blood pressure log if you have been diagnosed with high blood pressure is a very good way to be prepared to speak with your physician about this topic. You may also want to keep a blood pressure log if you have not been diagnosed with high blood pressure but are worried about it. This type of log can make it easier for you and your doctor to notice any changes in your condition.

Amerge and Heart Disease

Although extremely rare, serious heart problems – some of which have been fatal -have occurred after taking Amerge tablets. These problems have occurred most often in patients with risk factors for heart disease. Problems included:

  • Coronary artery vasospasm (blood vessels constricting in the heart)
  • Stroke
  • Heart attack
  • Rapid heart rate
  • Irregular heart rate
  • Transient ischemic attacks (TIAs or mini-strokes)

It is strongly recommended that Amerge not be taken by patients with heart disease risk factors including:

  • High blood pressure
  • High cholesterol
  • Smoking
  • Obesity
  • Diabetes
  • Strong family history of heart disease
  • Menopause
  • Male over 40 years of age


If you have any of these risk factors, have your doctor evaluate your heart and physical condition before taking Amerge.

In very rare cases, taking Amerge has resulted in serious — sometimes fatal — side effects, including irregular heartbeat and heart attack. For this reason, if you have heart disease risk factors and have never taken Amerge, your first dose should be taken in a doctor’s office or a similar setting with medical staff present.

Because of the risk of stroke, your doctor may choose to do an electrocardiogram (ECG) immediately following a dose of Amerge if you have heart disease risk factors.

If you have heart attack risk factors and continue to use Amerge after the first dose, it is recommended that you have your heart health monitored regularly.


What should you do if you experience possible cardiac symptoms while taking Amerge?

If you feel shortness of breath, heart throbbing, persistent pain, tightness or pressure in the chest or throat, especially shortly after taking Amerge, seek medical attention immediately.


Amerge and Kidney/Liver Problems

Amerge may cause problems if you have decreased liver or kidney function. For this reason, it is not recommended for people with severe liver or kidney disease. If you have mild to moderate problems with your kidneys and/or liver, your doctor should start you on a lower dose of Amerge. Also, you should not take more than 2.5 mg of Amerge within a 24-hour period.

Written & reviewed by: Lisa Erwin R.Ph. CGP | Last review date: Dec 2010.
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