Depakote ER Drug Interactions

Depakote ER Drug Interactions Overview

Depakote ER may interact with many other medicines. It is extremely important for you to tell your doctor about all the medications you are currently taking, including your over-the-counter (non-prescription) medications.

The migraine journal can help you keep a list of all of your medications so that any possible drug interactions can be evaluated. Do not stop taking any medication without telling your doctor.

 

Depakote ER Drug Interactions with Other Seizure Medications

Seizure medications (as well as other types of medications) that affect liver enzymes (the way some drugs are removed from your body) can alter the way valproate is removed from your body. Valproate can also affect the way some drugs are removed from your body and can include:

  • Phenytoin (Dilantin)
  • Carbamazepine (Tegretol)
  • Phenobarbital
  • Primidone (Mysoline)

 

If you take valproate alone or with any other seizure medications you should be closely monitored when starting and stopping either drug.

Other Depakote ER drug interactions with seizure medications include:

  • Topirimate (Topamax) – when taken together, a condition that causes too much ammonia in the blood can occur.
  • Clonazepam (Klonopin) — absence seizures can occur when these are taken together
  • Diazepam (Valium) Valproate can increase the amount of diazepam absorbed into the body.
  • Lamotrigine (Lamictal) – Serious skin reactions (such as Stevens-Johnson Syndrome and toxic epidermal necrolysis) have been found when patients take lamotrigine and valproate together.
  • Felbamate (Felbatol)

 

Other Drug Interactions

Depakote ER should be closely monitored when using the following other medications:

  • Aspirin
  • Carbapenem antibiotics (such as Primaxin)
  • Rifampin
  • Amitriptyline/nortiptyline
  • Warfarin (Coumadin)
  • Zidovudine
  • Tolbutamide

 

If you take valproate alone or with any other medications you should be closely monitored when starting and stopping any drug.

Written & reviewed by: Lisa Erwin R.Ph. CGP | Last review date: Dec 2010. Click the References Link below for a complete list of references.

Written & reviewed by: Lisa Erwin R.Ph. CGP | Last review date: Dec 2010.
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