Fioricet Drug Interactions

Fioricet Drug Interactions

Fioricet may interact with other medicines. It is extremely important for you to tell your doctor about all the medications you are currently taking, including your over-the-counter (non-prescription) medications. Fioricet contains a combination of 3 different medications so it’s important to check your medication list against each of these ingredients. The migraine journal can help you keep a list of all of your medications so that any possible drug interactions can be evaluated. Do not stop taking any medication without telling your doctor.

Check your current medications for:

  • Ingredients that can cause drowsiness
  • Drinks or other medications containing caffeine or caffeine-like products
  • Acetaminophen (Tylenol) — to make sure you don’t exceed the maximum daily dose of acetaminophen when you take Fioricet.


Fioricet Major Drug Interactions

(MAO) inhibitors used to treat depression can increase the central nervous system effects (brain slowing effects) of butalbital (an ingredient in Fioricet). Some examples of MAO inhibitors include Nardil (phenelzine)and Parnate (tranylcypromine).

Also when taking Fioricet, the effects of other drugs that act on the central nervous system may be increased. These include other narcotic pain relievers, alcohol, general anesthetics (used to block pain), and tranquilizers such as Librium (chlordiazepoxide) or Valium (diazepam), and sedative-hypnotics. Be sure to tell your doctor about any drug you are taking that may cause additional drowsiness or other symptoms including:

  • Certain antihistamines (such as diphenhydramine)
  • Sleep or anti-anxiety medicines (such as alprazolam, diazepam, zolpidem)
  • Muscle relaxants
  • Narcotic pain relievers (such as codeine)
  • Medicines for mental illness (such as risperidone, amitriptyline, trazodone).


Fioricet should not be used with sodium oxylate (used to treat narcolepsy) because very serious interactions may occur. If you are currently taking sodium oxybate tell your doctor or pharmacist before starting Fioricet.

Other Fioricet Drug Interactions

  • Adenosine (used to treat irregular heartbeat)
  • Anti-seizure drugs (such as carbamazepine, phenytoin)
  • Beta agonists (such as albuterol) used to treat asthma
  • Birth control pills

Fioricet Drug Interactions with Drugs Affecting Liver Enzymes

  • Erythromycin
  • Cimetidine
  • Disulfiram
  • Valproic acid
  • Fluvoxamine
  • Isoniazid
  • Lithium
  • Methoxyflurane
  • Phenothiazines (such as chlorpromazine)

Fioricet can also speed up the removal of other drugs from your body by affecting your liver enzymes including:

  • Blood thinners (such as warfarin)
  • Cyclosporine (used for organ transplant)
  • Corticosteroids (such as prednisone)
  • Estrogen (a female sex hormone)
  • Felodipine (a calcium-channel blocker)
  • Metronidazole (an antibiotic)
  • Quinidine (used to treat irregular heart rate)
  • Certain beta blockers (such as metoprolol)
  • Theophylline (used for asthma)
  • Doxycycline ( a type of tetracycline antibiotic)

Written & reviewed by: Lisa Erwin R.Ph. CGP | Last review date: Dec 2010. Click the References Link below for a complete list of references.

Written & reviewed by: Lisa Erwin R.Ph. CGP | Last review date: Dec 2010.
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