Fioricet Precautions and Warnings

Fioricet Precautions and Warnings

Fioricet can have a drug interaction with other medicines or not be a good drug for you if you have certain medical conditions such as severe breathing problems, or porphyria (an enzyme disorder). Be sure to tell your doctor about your medical history including any problems with kidney disease, personal or family history of drug or alcohol abuse, mental/mood disorders, stomach problems (such as stomach ulcer) or heart disease.

It’s important to know all of the medicines that you or your family member takes. Use the migraine journal to keep a list of all medicines to share with your doctor. Only your doctor can prescribe prescription medicines for you. Do not stop taking any medicine without speaking to your doctor.


Fioricet is not recommended if you have:

  • An allergic reaction to any ingredient in Fioricet (acetaminophen, caffeine or butalbital)
  • Porphyria (an enzyme disorder that causes a buildup of chemicals called porphyrins in your body)


Allergic reactions to these drugs mean you might be allergic to Fioricet as well

  • Barbiturates (such as phenobarbital)
  • Xanthine derivatives (such as theophylline)


Fioricet is Not Recommended for Children

The safety and effectiveness of Fioricet in children under the age of 12 has not been proven.

Fioricet Use in Older Adults

Studies of Fioricet did not include enough people age 65 and older to determine if they respond differently to the medicine than younger people.

If you are an older adult using Fioricet, you should usually start at the lowest possible dose recommended by your doctor. Older adults are at increased risk of liver, kidney and heart conditions and often have other health conditions and are taking other medications.

Butalbital (an ingredient in Fioricet) is heavily removed from the body by the kidney, and the risk of toxic reactions to Fioricet may be greater in people who have kidney damage. Because older adults are more likely to have kidney damage, they should usually start with the lowest possible dose recommended by their doctor. Older adults may also want to have their kidney function monitored while they are taking Fioricet.


Fioricet and Alcohol

Do not drink alcohol while taking Fioricet as it may make you dizzy or drowsy. Using alcohol while taking Fioricet makes an overdose, which may cause death, more likely. Fioricet contains acetaminophen, which may cause liver damage. Drinking alcohol every day and taking a medicine such as Fioricet that contains acetaminophen, may increase your risk for liver damage.

Remember: Mixing alcohol and medicines puts you at risk for dangerous reactions. Protect yourself by avoiding alcohol if you are taking a medication and don’t know its effect. To learn more about a medicine and whether it will interact with alcohol, talk to your pharmacist or doctor.

Written & reviewed by: Lisa Erwin R.Ph. CGP | Last review date: Dec 2010. Click the References Link below for a complete list of references.

Written & reviewed by: Lisa Erwin R.Ph. CGP | Last review date: Dec 2010.
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