Imitrex Drug Interactions

Imitrex may interact with other medicines. It is extremely important for you to tell your doctor about all the medicines you are currently taking, including your over-the-counter (non-prescription) medicines. The migraine journal can help you keep a list of all of your medicines.

Imitrex and Migraine Medicines:

Imitrex should not be used within 24 hours after another drug containing triptan (found in some similar migraine medications) or ergotamine (found in some migraine and cluster headache medications) because this could cause your blood vessels to constrict too much.

Imitrex and Antidepressants:

Imitrex is not recommended for patients taking an MAO inhibitor (monoamine oxidase inhibitor — a class of antidepressants) or within 2 weeks of stopping one.

Before using Imitrex, tell your doctor if you are also taking an antidepressant such as citalopram (Celexa), duloxetine (Cymbalta), escitalopram (Lexapro), fluoxetine (Prozac, Sarafem), fluvoxamine (Luvox), paroxetine (Paxil), sertraline (Zoloft), or venlafaxine (Effexor). Taking Imitrex with an SSRI (selective serotonin reuptake inhibitor — a class of antidepressants) or an SNRI (serotonin-norepinephrine reuptake inhibitor — a class of antidepressants) may cause a potentially life-threatening reaction called serotonin syndrome. Serotonin syndrome symptoms may include changes in your thinking, behavior or level of alertness (e.g., agitation, hallucinations, coma), changes in your heart rate, blood pressure or body temperature (e.g. fast heart beat, high or low blood pressure, fever), changes in your muscles and/or nervous system (e.g., sensitive reflexes, lack of coordination), and/or nausea, vomiting, and/or diarrhea.

Written & reviewed by: Lisa Erwin R.Ph. CGP | Last review date: Dec 2010. Click the References Link below for a complete list of references.

Written & reviewed by: Lisa Erwin R.Ph. CGP | Last review date: Dec 2010.
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