Migranal Drug Interactions

Migranal Drug Interactions: an introduction

Migranal may interact with other medicines. It is extremely important for you to tell your doctor about all the medications you are currently taking, including your over-the-counter (non-prescription) medications. The migraine journal can help you keep a list of all of your medications so that any possible drug interactions can be evaluated. Do not stop taking any medication without telling your doctor.


Migranal Drug Interactions with Drugs that Affect Liver Enzymes (CYP3A4 Inhibitors)

Examples of CYP3A4 inhibitors include

  • Ketoconazole and itraconazole — drugs to treat fungal infections
  • Ritonavir, nelfinavir, and indinavir; (protease inhibitors) used for HIV
  • Macrolide antibiotics (erythromycin, clarithromycin, and troleandomycin) — used for infections

Learn more about Migranal and Drugs Affecting Liver Enzymes

Other less potent CYP3A4 inhibitors include saquinavir, nefazodone, fluconazole, grapefruit juice, fluoxetine, fluvoxamine, zileuton, and clotrimazole.


Migranal Drug Interactions with other Migraine Medicines

  • Migranal should not be used within 24 hours of taking sumatriptan (Imitrex) or other 5-HT1 agonists (triptans) like Frova, Amerge or Zomig because of the potential combined effect on the heart.
  • Migranal should not be used within 24 hours of taking other drugs like Migranal called ergotamine containing or ergot-type medications or methysergide.

Other Migranal Drug Interactions

  • Beta blockers (like Inderal and Toprol) — drugs used to treat high blood pressure
  • Nicotine — because smoking can cause additional narrowing of the blood vessels and can lead to blocking of blood supply to the body.
  • SSRI’s — drugs used for depression (such as Prozac, Paxil, Celexa)
  • Drugs that constrict blood vessels like epinephrine, pseudoephedrine can cause increased blood pressure when used with Migranal.



With Migranal, no indication of drug-seeking behavior was seen in the clinical studies. However, your doctor will carefully evaluate you for a history of drug abuse and follow you closely, observing for signs of misuse or abuse of Migranal (such as developing a tolerance, increasing your dose, drug-seeking behavior). Let your doctor know if you have had any drug abuse or misuse in the past.

Written & reviewed by: Lisa Erwin R.Ph. CGP | Last review date: Dec 2010. Click the References Link below for a complete list of references.

Written & reviewed by: Lisa Erwin R.Ph. CGP | Last review date: Dec 2010.
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