Topamax may interact with other medicines. It is extremely important for you to tell your doctor about all the medicines you are currently taking, including your over-the-counter (non-prescription) medicines. The migraine journal can help you keep a list of all of your medicines so that any possible drug interactions can be evaluated. Do not stop taking any medication without telling your doctor.
Topamax Major Drug Interactions
Topamax use should be closely monitored for a drug interaction when it is taken by people who are using the following medicines:
Other anti-epileptic drugs (AEDs) such as Valproic acid (Depakote ER), Tegretol (carbamazepine),Lamictal (lamotrigine), Dilantin (phenytoin).
Drugs that affect the central nervous system, including alcoholic beverages and sedatives
Birth control pills: Taking Topamax with birth control pills may cause bleeding between menstrual periods and may make the birth control pills less effective.
Hydrochlorothiazide (sold as Hydrodiuril) — a water pill used for hypertension.
Glucophage (metformin): Taking Topamax can cause metabolic acidosis (when the kidneys aren’t removing enough acid from the body) which may be dangerous for people taking metformin at the same time.
Actos (pioglitazone): People taking Actos and Topamax should have their diabetes closely monitored.
Lithium (sold as Eskalith and Lithobid): Taking Topamax may affect lithium levels, which may mean you need your lithium dosage adjusted.
Amitriptyline (sold as Elavil and Endep): Your dosage of this medicine may need to be reduced while you are taking Topamax.
Carbonic anhydrase inhibitors such as Zonegran (zonisamide), Diamox (acetazolamide) or Daranide (dichlorphenamide): Taking these medicines with Topamax may increase metabolic acidosis (too much acid in the body) and the risk of kidney stones.
If you are taking any of these medicines along with Topamax, you may need your dosage of Topamax or your other medicine(s) to be adjusted in order to use them safely and effectively.
Written & reviewed by: Lisa Erwin R.Ph. CGP | Last review date: Dec 2010. Click the References Link below for a complete list of references.
Written & reviewed by: Lisa Erwin R.Ph. CGP | Last review date: Dec 2010.