Treximet Dosage

How to Take Treximet

Doses of Treximet work differently in different people. The dose should therefore be made on an individual basis, weighing the possible benefit of a higher dose with possible side effect risks.

Keep a migraine journal of what doses of Treximet you are taking when you experience a migraine. This will help you know if the medicine is working for you at the dose you are taking and can help you be prepared to discuss how well the drug works during your visits to your doctor.


Treximet Dosage

Treximet is a combination of sumatriptan (85 mg) and naproxen sodium (500 mg) within the approved dosage ranges (25 to 100 mg of sumatriptan and 220 to 825 mg of naproxen sodium).

  • The recommended Treximet dose is 1 tablet
  • Maximum daily dose of Treximet is 2 tablets (each taken at least 2 hours apart) in 24 hours even though it has not been proven that a second dose is effective.
  • The safety of treating an average of more than 5 migraine headaches in a 30-day period has not been established.


Learn more about Treximet and Overuse.

  • Treximet is not recommended for people with liver damage or kidney damage.


Learn more about Treximet precautions and warnings

Treximet is not recommended for people who have or have had:

  • High blood pressure which is not controlled
  • Hemiplegic migraine (migraine with stroke-like symptoms of extreme muscle weakness and paralysis) or basilar migraine (migraine with throbbing pain at the back of the head). If you don’t know, ask your doctor if you are not sure what type of migraine you have.
  • Problems with your liver.
  • Allergy to aspirin or any other NSAID like hives or asthma.
  • A heart attack or a history or symptoms of heart disease (such as chest pain or angina)
  • A stroke, mini-stroke, or other stroke-like syndrome
  • Ischemic bowel disease
  • Allergic reactions to sumatriptan, naproxen, or other ingredients in Treximet.


Do not take Treximet right before or after heart bypass surgery because it may increase the chance of a heart attack or stroke that can lead to death.


Treximet is not recommended for people with heart disease risk factors. Please discuss whether or not your risk factors prevent you from safely taking Treximet. Your doctor may do a heart exam to check for problems. Certain risk factors for heart disease include:

  • High blood pressure or cholesterol levels
  • Smoking
  • Obesity
  • Diabetes
  • Family history of heart disease
  • Female who has gone through menopause
  • Male over age 40


>Learn more about Treximet Drug Interactions.

Treximet Use in Children:

Safety and effectiveness of Treximet in children have not been established.

Treximet Use in Older Adults:

Treximet is not recommended for older adults who have liver or kidney problems, higher risk for coronary artery disease, and increases in blood pressure.

Learn more about Treximet and the potential benefits and risks by visiting Treximet Precautions and Warnings.

Written & reviewed by: Lisa Erwin R.Ph. CGP | Last review date: Dec 2010. Click the References Link below for a complete list of references.

Written & reviewed by: Lisa Erwin R.Ph. CGP | Last review date: Dec 2010.
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