Treximet Drug Interactions

Treximet may interact with other medicines. It is extremely important for you to tell your doctor about all the medications you are currently taking, including your over-the-counter (non-prescription) medications. It is also important to tell your doctor if you are taking any dietary supplements, such as herbs or vitamins. Your doctor can best help you avoid any unpleasant side effects if he or she knows about everything that you are taking. Do not stop taking any medication without telling your doctor.


Treximet Drug Interactions with Other Medicines Containing an NSAID:

Treximet contains an NSAID (naproxen). Taking another medicine containing an NSAID (Motrin, Aleve, Aspirin) can increase your chance of gastrointestinal side effects including GI bleed.

Treximet Drug Interactions with Antidepressants:

Treximet can interact with antidepressants called SSRIs and (SNRIs) including:

  • Celexa (citalopram HBr)
  • Lexapro (escitalopram oxalate)
  • Luvox (fluvoxamine)
  • Paxil (paroxetine)
  • Prozac/Sarafem (fluoxetine)
  • Symbyax (olanzapine/fluoxetine)
  • Zoloft (sertraline)
  • Cymbalta (duloxetine)
  • Effexor (venlafaxine)

Taking Treximet with an SSRI (selective serotonin reuptake inhibitor — a class of antidepressants) or an SNRI (serotonin-norepinephrine reuptake inhibitor — a class of antidepressants) may cause a potentially life-threatening reaction called serotonin syndrome. Serotonin syndrome symptoms may include changes in your thinking, behavior, or level of alertness (such as agitation, hallucinations, coma), changes in your heart rate, blood pressure, or body temperature (such as fast heart beat, high or low blood pressure, fever), changes in your muscles and/or nervous system (such as sensitive reflexes, lack of coordination), and/or nausea, vomiting, and/or diarrhea.

Treximet cannot be taken within 2 weeks of taking a class of antidepressants called monoamine oxidase (MAO) inhibitors including

  • Marplan (isocarboxazid)
  • Nardil (phenelzine)
  • Parnate (tranylcypromine )


Treximet Drug Interactions with Other Migraine Medicines

  • Ergotamine-containing medicine (Ergot-containing drugs have been reported to cause prolonged sudden restrictions of blood vessels.)
  • Another triptan medicine.


Other Drug Interactions Include

  • Methotrexate: Naproxen sodium and other NSAIDs may increase the toxic effects of methotrexate.
  • Aspirin: Taking Treximet along with aspirin is not generally recommended because of the risk of increased side effects.
  • Angiotensin-Converting Enzyme Inhibitors NSAIDs may reduce the effectiveness of ACE inhibitors, drugs commonly used for high blood pressure and can worsen kidney function. .
  • Furosemide: NSAIDs can reduce the function of your kidneys. If you are taking Treximet and furosemide, you should be monitored for signs of kidney failure.
  • Lithium: NSAIDs elevate the amount of lithium in your blood and reduce your kidney’s ability to remove it from your body. If you are taking Treximet along with lithium you should be monitored closely.
  • Probenecid: Probenecid increases naproxen levels in your blood levels and significantly increases the time the naproxen remains in your body.
  • Propranolol and Other Beta-Blockers:

    Naproxen and other NSAIDs can reduce the ability of propranolol and other beta-blockers to lower your blood pressure.

  • Warfarin: Taking NSAIDS and warfarin increases your risk of serious gastrointestinal bleeding.


Written & reviewed by: Lisa Erwin R.Ph. CGP | Last review date: Dec 2010. Click the References Link below for a complete list of references.

Written & reviewed by: Lisa Erwin R.Ph. CGP | Last review date: Dec 2010.
View References