Treximet Precautions and Warnings

Treximet Precautions and Warnings introduction

Treximet can have a drug interaction with other medicines or not be a good drug for you if you have certain medical conditions, such as heart disease, liver or kidney problems. It’s important to know all of the medicines that you or your family member takes. Use the migraine journal to keep a list of all medicines to share with your doctor. Only your doctor can prescribe prescription medicines for you. Do not stop taking any medicine without speaking to your doctor.


Treximet is not recommended for people who have or have had:

  • High blood pressure which is not controlled
  • Hemiplegic migraine (migraine with stroke-like symptoms of extreme muscle weakness and paralysis) or basilar migraine (migraine with throbbing pain at the back of the head). If you don’t know, ask your doctor if you are not sure what type of migraine you have.
  • Problems with your liver.
  • Allergy to aspirin or any other NSAID like hives or asthma.
  • A heart attack or a history or symptoms of heart disease (such as chest pain or angina)
  • A stroke, mini-stroke, or other stroke-like syndrome
  • Ischemic bowel disease
  • Allergic reactions to sumatriptan, naproxen, or other ingredients in Treximet.

Treximet and Heart Risk:

Please discuss whether or not your risk factors prevent you from safely taking Treximet. Your doctor may do a heart exam to check for problems.

TREXIMET is not recommended for people with heart disease or risk factors and should not be taken right before or after heart bypass surgery


Certain risk factors for heart disease include:

  • High blood pressure or cholesterol levels
  • Smoking
  • Obesity
  • Diabetes
  • Family history of heart disease
  • Female who has gone through menopause
  • Male over age 40


Treximet and Medicines to Avoid

Taking Treximet with NSAID medicines (like Advil, Motrin, Aleve) many of which are available over the counter (OTC) can increase your chance of having an ulcer (bleeding in the stomach) and can happen any time during use of these medicines.

Be sure to tell your doctor about any other medicines you are taking which may contain an NSAID.


Tell your doctor about all the medications you are taking or have taken in the past 2 weeks including antidepressants called monoamine oxidase (MAO) inhibitors as well as any other migraine medicines you are taking.


Learn more about Treximet Drug Interactions.

Treximet Use in Children:

Safety and effectiveness of Treximet in children have not been established.


Treximet Use in Older Adults:

Treximet is not recommended for older adults who have liver or kidney problems, higher risk for coronary artery disease, and increases in blood pressure.


Treximet and Alcohol:

Limited information exists on the use of alcohol with Treximet. It is not recommended that you drink alcohol while taking Treximet.

Additionally, Treximet contains naproxen sodium, a non-steroidal anti-inflammatory medication. NSAID-containing medicines, such as Treximet, can cause ulcers and bleeding in the stomach and intestines at any time during treatment. The chance of you getting an ulcer or bleeding increases when you drink alcohol.

Remember: Mixing alcohol and medicines puts you at risk for dangerous reactions. Protect yourself by avoiding alcohol if you are taking a medication and don’t know its effect. To learn more about a medicine and whether it will interact with alcohol, talk to your pharmacist or doctor.

Written & reviewed by: Lisa Erwin R.Ph. CGP | Last review date: Dec 2010. Click the References Link below for a complete list of references.

Written & reviewed by: Lisa Erwin R.Ph. CGP | Last review date: Dec 2010.
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