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Have you experienced any side effects from CGRP medications?

If you have tried any of the new CGRP medications (Aimovig, Ajovy or Emgality) have you experienced any side effects? If so, which treatment have you tried or are you taking?  What side effects have you experienced?

How many doses did you or have you taken? Do you recall what dosage amount?

Please share your feedback & experiences with our community! If you’d like to explore what some of our members have already shared (both positive and negative), be sure to take a look at our forum page which you can find here.


Community Answers
  • Cappucinno
    4 months ago

    I just read most of the answers about side effects of CGRPs and what help if any. I am now on my 7th dose of Aimovig (every 28 days) starting in Sept. 2018. I have not had any side effects from this drug and I have had good results. I used to get between 15 to 20 migraines of varying degrees per month. I am now at about 4 to 6 mild to moderate migraines per month. I am very happy with these results and I am now starting to feel a bit more positive about what I can plan for my days ahead.

  • sjogreen
    4 months ago

    Loading dose of Emgality, plus two more single injections 4 weeks apart. Injection site always looks like someone stabbed me. Hives every single time on my face and chest with a lingering red splotch all over my face, increased BP, never poop, and 14lbs of weight gain.

    I saw someone asking in another thread about latex allergies and correlation to side effects. I’m allergic to avacados and my allergist says they have a similar naturally occurring latex property…hummm?

  • jenrene
    4 months ago

    My first dose of monthly Ajovy was less than 3 weeks ago and I’ve been experiencing things I never have before… such as high blood pressure. I’ve always had perfect BP or even lower than “normal” BP my entire life but not now. My heart rate has been over 120 also, even when I’m sleeping. I’ve felt lightheaded and nauseous but was told it was vertigo. 7 days after my first injection a horrible migraine started, it lasted 5 days and was one of the worse I’ve experienced in over 5 years. I’m not sure if Ajovy is the culprit or not but I’m afraid to move forward with next injection.

  • arden
    4 months ago

    I am on my 5th month with Aimovig and have had good results. Episodic migraines down to nearly nothing and when I do,get an attack there is very little pain. Side effects are insignificant. This is miracle science similar to when Triptans came out. I am thankful indeed.

  • Tom Picerno moderator
    4 months ago

    @arden it’s great to hear that you’ve had such great relief from Aimovig! Thanks for sharing your experience. Be well

  • Janet
    4 months ago

    I’m saddened by the wonderful start I had with AIMOVIG (last July …140mg) to me developing AWFUL side effects beginning last December and up until today .

    The feelings of fatigue, nausea, insomnia ..tingling sensation running down both my legs..break through migraines that began this past January with aura ( which I hadn’t had in over a decade, aura I mean)..and vertigo which prior to AIMOVIG maybe I experienced a couple times in the 40+ years I’ve suffered chronic migraine.

    I’ve been stuck in my house for 3-1/2 months now due to what I can only assume are the horrid side effects just emerging 3 months ago from AIMOVIG as the culprit.

    My heart aches and breaks since I did not experience one ill effect from AIMOVIG…only joy…not one break through migraine for 6 months!!!! Not one triptan!

    My neurologist retired last December and his replacement, while very qualified, told me at my appointment last week that I had to BEG for said he doesn’t know enough about AIMOVIG or the other cprg injections to help me. He said I need a headache specialist….he said while he has maybe 25 patients on cprg injections vs their expertise with probably hundreds of patients maybe, ( I doubt that) I couldn’t believe he didn’t offer me anything….we , well I walked out in tears…”I CANT HELP YOU” he said…don’t ever tell a patient you can’t help them…there’s always something…my gosh his credentials and specialities of ailments he treats is quite impressive…I was and still am heart broken….

    …well I have horrible insurance (HMO) so I’m on the bottom of any pile there is. There are only 2 headache specialists where I live (Las Vegas) and both have been my doctor. Neither can see me until MAYBE June. Actually one of the doctors receptionist gave me no hope of an appointment. So my current neurologist sent me on my way with NO help WHATSOVER ! 🙁
    When I say insomnia I mean NO SLEEP AT ALL! I do fall asleep..awaken about 2 hours later then I’m awake from midnight all through the night…..functioning is impossible and anxiety is at a new high…I have to lay down during the day and crying will eventually get me a 30 to 45 minute nap.

    My husband has researched and come up with nothing. He called my primary care physicians office and begged for help…usually it’s months to get in there also, but Monday isn’t too far away in the scheme of my 3-1/2 months of nightmare.

    So now here I sit, after a vestibular migraine Tuesday night…insomnia…I didn’t get up yesterday because I couldn’t until 5 pm…my husband wanted me to hydrate and eat.

    He sat with me until 11pm…got up..the vertigo came back..took a Dramamine less drowsy and did get 3 hours of sleep….today is postdrome and I’m on the couch writing my story…one I thought I would,never have to write…my March injection day was the 4th and when I see them in the refrigerator I think, gosh..I never thought if they worked from the get go that that would end…how naive … I’m glad for those who are helped by cprg, but I won’t try again….I’m afraid of what my blood work will show…but that’s just another bridge I’ll be crossing thankfully with a husband who is the only support system I have….all friends and family pretty much dropped by the wayside ..life happens….and for 6 months I had mine back..I just wasn’t ready for it to be over.

    Best of luck to you all,
    Janet Jones

  • Lise Paul
    2 months ago

    Janet,
    I am so sorry to read your story here. Bless your husband for helping out! I landed in the ICU for 5 weeks after 6 months of infections and compromised immune system while taking Aimovig. Almost died. I will never take a “new to market” drug again. I was so looking forward to these CGRPs but they are not for everyone.

  • Tom Picerno moderator
    4 months ago

    @janet I am so sorry to hear about your unfortunate experience with Aimovig. I can only imagine how your elation after the initial shot was wiped out by all the side effects. I’ve had some insomnia after starting Ajovy but I find that melatonin or my prescription for tizanidine seems to work for me. I would jot down some questions and goals to cover with your primary doctor at the next visit. I know you mentioned there are only two headache specialists in your area so you may need to consider widening your search to find a doctor to provide you with some relief. Here is a link that may help. https//migraine.com/blog/looking-for-a-migraine-specialist/
    I truly hope you find the relief you desire.

  • Janet
    4 months ago

    Thank you so much for your response to my post! I’m sitting in the pcp office now with all my questions. I was up again ALL night after 2 hrs sleep..awake from 1am until I had to get ready for doctor..this is unnerving!.I think I’m having withdrawal from aimovig..the headache specialists I said I was told to go to have been my doctors in the past and have no interest in taking be back 🙁
    Since I have hmo I will have to wait even though I told both offices I would pay cash…I’m sad for me since I FINALLY thought I had the miracle prevention medicine that would last..not just 6 months..I’m angry I was stupid enough to continue injecting 2 more months before checking websites to realize I am experiencing what so many others are …
    Thank you again
    Janet

  • petroleum
    4 months ago

    I have taken 2 doses of Ajovy and have felt much, much worse. After the 2nd dose I had an red spot the size of the palm of my hand in less than 24 hours. It was hot and it ached. It took 2 weeks before it started fading and looked like I had the measles. I have had daily auras, vertigo, dizzy episodes, often several times a day. My head also started throbbing right after the first injection and has continued throbbing. It never throbbed before. I just couldn’t make myself take the 3rd dose. My neurologist suggested I wait a couple more weeks and then try again saying it sometimes takes 3-4 doses before you notice relief. Right after that appointment I had an appointment with my primary care doctor with fasting blood tests. My thyroid levels were out of whack, my triglycerides had doubled, my entire metabolic panel was awful. He said I was a metabolic disaster. I’d had the same tests done in early December prior to the first dose of Ajovy and the results were fine. The only change between then and now is the Ajovy. I go back for another set of lab tests in a month and hope that things are back to normal. I can only assume at this point that the Ajovy is the cause. And while Ajovy is not supposed to cause constipation, for me it does. At this point I doubt I will be doing another injection.

  • deedeevee1
    4 months ago

    I’ve taken 3 doses. 140mgs ea. It seems to have made my vertigo worse. Much worse. And I’ve had significant trouble moving my bowles. Also, it seems it has increased my blood pressure which increases my dizzy spells. I’m being told to hang in there. It’s the acclimation process. But I don’t think I can handle much more.

  • Janet
    4 months ago

    I would think LONG and HARD before you inject yourself again..I started off GREAT with AIMOVIG and now, once again, migraine abs a medication, had robbed me of my life 🙁

    I’m glad you have a doctor you trust and seems willing to keep trying..in my experience with chronic migraine (40+years YIKES) doctors do give up on you…it has happened far too often…right now I’m at another dead end. My post is above..please take a moment to read..I have reported my adverse side effects to amgen and the FDA..I wish all the awful things I’ve read here and other websites written by fellow migraine sufferers using these new CPRG injections report their side effects so maybe others will research more before jumping on the vand wagon to start something so new…this happened to me with topomax…it was on the market only a few months..not even..before I tried it..worked great until it didn’t.

    Thanks for listening..Janet

  • pigen51
    4 months ago

    I have taken 3 doses of 140 MG each. Not only has the medication not worked yet, but the side effects are disturbing. When they say that one of the worst side effects is constipation, they are not kidding.
    You probably don’t want to hear the entire story, but let me just say the day that I finally got things moving again, I spent about 8 hours or so just dedicated to that entire process.
    I also had some cramping of my thigh muscles, although those were not horrible, just annoying.
    My neurologist tells me that it can take up to 6 months to take effect for Aimovig.
    The really great thing is that he is not putting all of his eggs in one basket. If this doesn’t work, then he has a plan to try something else. He is only a year or two out of residency, and is very intelligent, and very optimistic. I have never had a neurologist like that before. And I have not been able to find a neurologist who would even take me anymore, since I have already been to all of them around here, and they have given up.

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