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CGRPs (calcitonin-gene-related peptide)

CGRP and chronic migraine with gastric stasis

  • By USMCwife

    Does anyone know if the CGRP drugs also relieve the nausea, vomiting, and diarrhea associated with gastroparesis related to chronic migraine? Basically, I’m wondering if I respond well to the CGRP (fingers crossed), will I then need to continue treating the nausea and vomiting or will it get better as well? Can’t seem to find any information about that. I have 25 attacks a month on average, but the nausea and vomiting are constant. I haven’t had a day without nausea in a year and I vomit at least one day a week. I used to have to go to the ER to get IV fluids and IV phenergan at least once a month, but I’ve gotten better about oral rehydration and treating the nausea (one way or another) before I vomit myself into dehydration.

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  • By Nancy Harris Bonk Moderator

    Hi USMCwife,

    Great question!! Thank you for reaching out to us.

    Good to hear you’ve been able to treat your symptoms better, that’s always good news!

    The new CGRP migraine prevention medication will work to prevent migraine attacks. So in theory, and I don’t know if anyone has data on this, the nausea, vomiting and other gastric symptoms that accompany a migraine attack may be less seeing as the goal of the medication is to reduce migraine attacks.

    I know that’s not a complete answer, and I wish I had more information for you. If I come across more, I will share!

    Let me know what you think
    Nancy

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  • By GardensatNight

    That’s a good question. I don’t have that exact problem, but a similar issue, because what disables me more than the headaches themselves is chronic light sensitivity… but I haven’t seen any data from the studies on anything but headache frequency reduction. I would guess for cases like ours, we would likely just have to try it and see if it does reduce headache like Nancy is saying, and if they overall calming of the brain helps other things as well (that’s my current fingers crossed theory…. we’ll have to see. I hope people who get to try the drugs will post their experiences.)

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  • By carolelynn

    Hi USMCwife, I just joined a few weeks ago and just saw this. Not sure you’re still following this discussion. I have gastroparesis as well. I have an autoimmune disease that has pretty much decimated my GI system so I was concerned about trying the Aimovig. Well, I did about weeks ago and it’s been a miracle worker for my migraines and I haven’t noticed any change with my gastroparesis. (At the same time, I am so caution and limited as to what I eat maybe that’s why.) I’ll certainly let you know if that changes. Have you tried the Aimovig yet?

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