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Medications & Prescription Treatment

Methazolamide

  • By vitamin_migraine

    My neurologist has placed me on methazolamide after a Lamictal intoxication and an adverse reaction to Dopamax. My primary problem is “aura continua” (status migrainus with or without extensive pain but never ending and debilitating auras). Triptans are generally poorly tolerated and tend to create a headache where there might not be one and so far I mostly rely on steroid combos. Literature on the use of methazolamide for this purpose is borderline inexistent.

    Any one have any experience with this?

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  • By Nancy Harris Bonk Moderator

    Hi vitaminmigiraine,

    I’m sorry you are having a difficult time finding a preventive regime that helps. Persistent aura is a problem for a small number of people with migraine and you’re correct – there is not a lot of data on treating this. There is some anecdotal evidence that acetazolamide, brand name Diamox (which is similar to methazolamide) and valproic acid (Depacon) have helped some with persistent aura. This page has good information on this type of aura; http://www.migraine-aura.com/content/e25968/e26078/e26305/index_en.html.

    Here is a research poster with interesting information on this topic; https://www.bcm.edu/departments/neurology/pdf/poster_other_VisualAura.pdf.

    I take methazolamide for idiopathic intracranial hypertension (https://migraine.com/blog/migraine-comorbidities-idiopathic-intracranial-hypertension/ and find it helpful. But this is different from persistent aura.

    Something to keep in mind is it can take up to three months before we see a reduction in our migraine symptoms. Also as our body adjusts to the new medication potential side effects may lessen.

    Please keep us posted on how you are feeling,
    Nancy

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