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Medications & Prescription Treatment

Midrin

  • By Ellen Schnakenberg

    As far as I know, Midrin is no longer available. Teri Robert and I were discussing whether it was legal for compounders to make it. Neither of us was sure.

    I saved back a couple of doses worth because I do agree with you Gregory – while it didn’t always do 100% of the job and was not so good for a real whopper, sometimes using it in combination was helpful to me personally. It definitely was one that, since I can’t take Triptans any longer, I could take immediately as soon as I knew I was headed for trouble and it would often stop things before they got too out of control. I always had to take the max dose, but so long as it worked I was okay with that.

    I’m not actually even for sure why this isn’t available anymore. It’s a shame though.

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  • By Jamie

    Teri Robert wrote an about Midrin being discontinued: http://www.helpforheadaches.com/articles/2010/Discontinued-Migraine-Medications.htm.

    I agree with both of you – it didn’t completely eliminate the migaine pain, but it was better than nothing. The Triptans don’t work at all for me. I was maxing out my Midrin usage, so my neurologist changed me to a different abortive medication. But, it works about as well as the Midrin did… and, he said that this is the last medicine option he has (he actually said that he’s out of ideas/options). I agree, Ellen, it’s a shame that it’s not available anymore.

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  • By Teri Robert

    These medications were developed before the current FDA approval process was put into place. Manufacturers have had years to apply for FDA approval, bu none had, so the manufacturers discontinued making them to comply with FDA regulations. I’ve been working to find out if any of them are going to be back, and the good news is that Epidrin will probably be back by early spring. You can read a full update as of today (Jan. 16) at http://www.puttingourheadstogether.com/2011/01/migraine-and-medications-like-midrin-11611-update.html.

    Hope this is helpful!

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  • By Gregory Gauthier

    I do not know where you are located , but I have had absolutely no problem obtaining the Epidrin (Midrin equivalent) here in Florida, at my Publix pharmacy. I have been getting the script filled monthly without any delays.nI was very surprised when I started reading about it reportedly being discontinued. I have been on it (approx 8 months).

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  • By Jamie

    Teri, I’m glad to hear that Epidrin might become available again. I hope I won’t need to take it in the future, but it’s a medication that helped to the same degree as the one I’m on now. Thank you for the update.

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  • By Teri Robert

    Gregory,

    If you can, it wouldn’t hurt to fill it now while your pharmacy has it. Excellium is applying for FDA approval, but you never know how long it will take.

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  • By Teri Robert

    Sorry, Gregory.

    There are a couple of options. Prodrin contains isometheptene mucate and acetaminophen like Epidrin did, but not the sedative ingredient. It has caffeine instead. It’s still being made and shipped. You can also get a prescription to take to a compounding pharmacy.

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  • By Anonymous

    Want to let everyone know that I am a compounding pharmacist and I can compound Midrin (Isometheptene Mucate, Dichlorophenazone, aceteminophen). This is perfectly legal. I am a pharmacist compounding upon receipt of a written prescription for a specific person, not a bulk manufacturer and therefore I am not subject to FDA rules/regs on manufacturing.

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  • By Ellen Schnakenberg

    Gregory, any compounding pharmacist can assist you in having medications made specifically for your personal circumstance. Compounding pharmacists are often associated with hospitals, and many doctors know which pharmacists locally might be able to help you. When in doubt, a simple phone call to your favorite pharmacy will often yield you the information you want 🙂

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  • By cynthia

    Does anyone know as of today (04/29/2011) if any company is doing what is necessary to start production of Midrin again? None of the other medicines work. I even get multiple injections into my neck and back of the head, but only Midrin makes them “bareable”. Any further information would be wonderful.

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  • By Teri Robert

    Cynthia,

    No, none of the companies are going to do the clinical trials and apply for FDA approval. To continue using a Midrin-like medication, a compounding pharmacy seems to be the only option.

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  • By nagg1979

    i found on another site in response to midrin being discontinued that a compunding company in delaware was still making midrin at only $1 a pill – **Post edited by moderator. Please do not provide personal contact information in public forums. **

    you just need a prescription from your doctor for as many pills as you would like and within a week they send it out to you by ups with a shipping cost of $10 – these prices are amazing compared to what i was paying at the pharmacy hen i could get them locally – i HIGHLY recommend this company and suggest that you spread the word to any and all migraine sufferers everywhere ! their customer service is superb as well – good luck!

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  • By AR

    I was recently able to get the last of Epidrin(Midrin) from my NJ pharamacy. **Post edited by moderator. Please do not provide personal contact information in public forums. **

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  • By gharris5

    A pharmacy in Lexington, Ky is compounding Midrin (and yes it is legal to compound if it’s done per a patient specific prescription). They can mail to most states.

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  • By maki808

    You can still get midrin. I found a pharmacy that can legally make midrin. They also mail it to your home for free too. It cost me about $1 a pill since I get mine in bulk of 100. It might cost a little more if you’re only getting about 30 pills. I guess it’s the time it cost for them to make so it’s worth while to let your doctor know…to prescribe a little higher amount with no refills. **Post edited by moderator. Please do not provide personal contact information in public forums. **

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  • By hannibails

    I was able to get Midrin generic from my pharmacy here in Maine. I gave the pharmacist the info I read here about Macoven Pharmaceuticals. He made a call to his wholesaler and got the generic-brand-name Isomethept-Dichloralp-Acetamin capsules and I was FINALLY able to get it after a year without it due to it being unavailable. This is the only medication that actually worked for me, and I was so upset about it not being manufactured. I am SO thankful I found your website and Teri Robert’s information about Macoven Pharm. Thank you, thank you!!!

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  • By beckerkc

    I just got some midrin at my pharmacy in KC. I was just lucky to call when I did, because they said they don’t always know when they are going to have it. Theirs came from Macoven.

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  • By taralane

    This is the best news I have heard in years! Midrin was not the best all over pain reliever for an acute attack but it did get rid of the daily migraine and took the edge off the early part of the migraine as it was settling in.

    I have missed having access to this wonderful drug with no after effects that I had to spend 2 days getting rid of.

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  • By taralane

    I went to a local compounding pharmacy about a week ago to find out if they could compound Midrin, and I was told they did not have to, they could order it, so to have my Doctor send them the Rx. So my doc. did, and after paying $256.84 because my insurance would not cover it – something about it not being approved by the FDA – I got my prescription, all 90 pills. It is too expensive for me to purchase on a regular basis, but I am running out of meds that are not in the MOH category, and it is very good to know that I can use this drug which now has helped me with the milder #4-5 migraines I deal with on a daily basis so I can have a day mostly pain free.

    I went to CVS, just to see what they knew as a check, and the pharmacist there knew nothing about the drug other than it had been discontinued.

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  • By Ellen Schnakenberg

    hangingbyathread – You might take a moment and look up the ingredients of the capsules you got. There may be an inert ingredient there that could be causing your gastric issues. Compounding could potentially eliminate that, but it will be more expensive I fear.

    On MOH, Midrin can contribute to MOH as well. You’ll want to be really careful about its use too, okay? I wish we had more options, but at least this seems to be helping you for now.

    Thanks for the update too 🙂 I’m glad you have something that will help. Even tiny baby steps in the right direction is still progress

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  • By taralane

    Thanks Ellen, I just saw your reply, when I was reading about someone having trouble getting the pill version from Macoven. I took it almost every day for the first 6 weeks I had it, but now I have tapered off and am not taking it more than once or twice a week. It also seems as though the daily migraines are getting better as well, and I am having better days with less pain.

    Just the last two days, as the weather changed from cool to very warm I’ve been hit with two migraines that I needed Axert to quell the pain instead of going for the Midrin, and have had loads of auras preceding, so I am hoping these stop soon and I don’t go back to the stabbing migraines I was getting for a while there. With intractable migraines, every day is a new day!

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  • By pooh2you

    We get just the Isometheptane portion of Midrin compounded for my daughter – that and Fiorocet are the only meds that work for her. (too bad Fiorocet puts her out)

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  • By texgrilln

    FYI: I just found this company/laboratory here in the USA that I contacted earlier today asking about their Midrin replacement and its availability. Here is their response:
    “We will have Larkadrin in here for distribution in Mid January. It is a new product for us.”

    Thanks,

    Kay
    Kay Ciarletta
    Operations Manager
    Larken Laboratories, Inc.
    276 Nissan Parkway, Bldg A, Suite 200
    Canton, MS 39046
    888-527-5522 / 601-855-7678
    Fax: 601-855-7676

    Hope you are having a blessed day!!

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  • By dawnschneider

    I just started Midrin today. I live in NY, and had no problem getting it. My Medicare part D insurance denied coverage, so I paid out of pocket for it. I have frequent migraines and NDPH-New Daily Persistent Headache. I’ve had that for 3 years now. I’ve been on so many medications, I can’t remember them all. I’ve tried nearly every triptan, and none have worked, except for Maxalt MLT. But, just like other medications, my body built up a tolerance, and it is no longer effective. My Neurologist has me on Midrin for 6 days starting today, then on an as needed for migraine only basis. We’re trying to get my pain level back down to its usual number. Daily its usually a 4-5, but lately, I’ve been at 7-8. Hoping this helps.

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  • By Nancy Harris Bonk Moderator

    Hi Dawn,

    I hope it works for you. I wonder if you have a Midrin equivalent…either way if it works great. Midrin and/or its equivalents are abortive medications, that stop the migrainous process (like Maxalt) and should only be taken two to three days a week. Taking it more than that can create another problem called medication overuse headache, and nobody wants that! I see Ellen gave you some information our FB page about MOH and I would strongly encourage you to read it.

    Maybe it is time to seek out the expertise of a true migraine specialist who treats migraines and headaches all day, every day? Just a thought. Here is some information for you on this; https://migraine.com/blog/looking-for-a-migraine-specialist/. Let me know what you think.

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  • By CM

    Dawn,

    Have you tried more than just triptans and abortives? I have Chronic Daily Migraine and triptans aren’t usually effective for people like us, unfortunately. When you get a migraine every day, trying to use abortives for it will just make it worse because you’ll start getting rebound headaches.

    Have you considered something like antidepressants (SSRI’s)? I had fantastic luck with Elavil (Amytriptyline) for a long time. Prophylaxis is going to help you a LOT more than trying to find an abortive cocktail that works well.

    However, I do find that midrin works well for me when I’m getting a less serious migraine (a 6 or 7).

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  • By Nancy Harris Bonk Moderator

    Hi CM,

    Midrin because it has acetaminophen in it can also create medication overuse headache. It’s best not to use migraine abortive medications such as the triptans or ergotamines or any kind of pain medication — prescription or over-the-counter — more than two or three days a week can make matters worse by causing medication overuse headache (MOH), aka rebound.

    You are correct about prevention, anyone who has more than three migraine attacks a month needs to talk to their doctor about migraine prevention medication.

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  • By Eseral

    Midrin is the ONLY thing that works for my almost daily Migraines. I tried to find the current Manufacturer of it, as I am disabled from these migraines and cried when it became unavailable 2 years ago. Magnum, the migraine site, does not have accurate information and has no discernible way to contact them to correct it. The fact is, I spoke to the previous manufacturer, Caraco Pharmaceuticals, today. They said that the FDA had not approved it and that they were no longer making it and didn’t know who was! I am absolutely horrified at the thought that I will be suffering with daily Migraines after my current supply is gone. I paid a very hefty price for them too – $165 for 60. That is virtually 15% of my monthly income.

    DOES ANYONE KNOW WHO IS CURRENTLY MANUFACTURING MIDRIN OR IF IT IS SOON TO DISAPPEAR AGAIN?

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  • By Teri Robert

    Eseral,

    We’ve been covering the Midrin situation since the beginning. You can find the most recent information in Midrin for Migraine: October, 2011, Update at https://migraine.com/blog/midrin-migraine-october-2011-update/

    How many days a week are you using this medication. If you’re using it more than two or three days a week, it could actually be making matters worse, not better. Please take a look at https://migraine.com/blog/living-with-migraine/help-how-can-i-not-overuse-migraine-medications/

    I hope this helps,
    Teri

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  • By Eseral

    Teri – Thank you very much for all of the research and info you have made available. I, too, was given the name of Macoven Pharmaceuticals as who was at least distributing Midrin (Epidrin), but when I went on their site on a Sunday, I did not see it listed on their Formulary and thought I had been misinformed. I plan to call them soon to inquire about whether or not they have a program for people like me who are on a VERY limited income (I am literally disabled due to my migraines) and need help acquiring this medication at a lower cost. Will post whatever I find out.

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  • By Teri Robert

    eseral,

    The Macoven product doesn’t have a brand name. On prescription bottle labels, it’s simply listed as Isometh/Dich/Apap capsules. I don’t think they list all their products, so you’re probably going to need to call them if you have questions.

    Teri

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  • By Jeff Rapp

    I posted this under Macoven Pharmaceutical but thought I would also post it here as well. Starting on January 1 or after I filled my last prescription of Midrin, Anthem will no longer pay for Midrin. I was told because it is no longer an FDA approved drug. If you are lucky and your insurance is still paying, I would stock up. Otherwise you will pay out of pocket, if you choose. For my local CVS it was going to be $300 for 60 pills. Needless to say, I did not fill it. I hope someone tries for FDA approval, but I am not holding much hope.

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  • By kitta4

    I don’t know whether generic Midrin is being manufactured now, because I use generic compounded “cafergot” which is no longer available by brand name, nor is it available in retail pharmacies.

    But, I know that the compounding pharmacy that makes my caffeine/ergotamine preparation (pills) for me also makes generic compounded midrin.

    What is interesting to me is that I am paying out of pocket for the compounded “cafergot” but it is cheaper than it was when I had insurance. I guess this is because compounded drugs are wholesale??

    If anyone needs midrin, or its generic equivalent, ask around for a compounding center. There are lots of them. And they will often mail to other states, if their license permits . My retail pharmacy told me about the compounding center, which was right down the road.

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