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Prevention Medications

Sodium valproate

  • By Anonymous

    My doctor has suggested sodium valproate as a preventative med for my 25 year migraine problem, but I’m scared to try it. Previously 8 weeks on carbamazepine left me with virtually constant vertigo/dizzyness, feeling drunk and hung-over at the same time, which lasted for over two years after stopping that drug. Then years later I tried topiramate and got dizzy after the first dose, so immediately stopped the drug with no repercussions that time. Has anyone any experience of sodium valproate? (epilim, epival, convulex, episenta, depakote) I would find it most useful to hear your experience with this drug please.

  • By Nancy Harris Bonk Moderator

    Hi Anonymous,

    Thanks for your question. Many people have good results with this medication, but something to keep in mind is what works for one person may not work the another and vice versa. The American Academy of Neurology and the American Headache Society came out with guidelines in 2012 stating the antiseizure medications like valproate, have ‘strong evidence’ that they are effective for treating migraine. You can read more about that here;

    I did want to mention it can take up to 90 before we see a reduction in our migraine frequency and severity when we start new medications. During this time potential side effects may lessen as well. If we don’t give each medication a fair trial, we’ll never know if it would have been “the” one to work.

    Good luck,