Skip to Accessibility Tools Skip to Content Skip to Footer

Forums


CGRPs (calcitonin-gene-related peptide)

Switching CGRP based meds?

  • By Krystolla

    Last fall I tried Amiovig but found that it worsened the severity of my migraines (much sharper pain) so I stopped taking it. My neurologist wanted to know if I was interested in trying one of the other CGRP based drugs – Emgality or Ajovy.

    Has anyone else switched from one CGRP drug to another? Did you experience different results or different side effects?

    I’m hesitant because it’s a lot of money and the pain last time was scary, but I also don’t have a lot of options available.

    reply
  • By beachbumgirl

    Hi Krystolla-
    I also had a worsening of migraines with Amiovig. Yet the next two
    anti CGRP drugs work a little differently I’m told. Speak with your
    Headache Specialist and decide
    If trying one or both would be in your best interest.

    Best of luck. Please let us know
    What you decide.
    Carol.

    reply
  • By Nancy Harris Bonk Moderator

    Hi Krystolla,

    That’s a great question!! I know a number of people with migraine disease who have switched from Aimovig to Ajovy or Emgality with good results.

    Each of these CGRP medications work a bit differently and people who have a hard time Aimovig seem to do better with one of the others.

    I hope that helps!
    Nancy

    reply
    • By daltal10

      Hi
      I had the Amovig injection two weeks ago and there is no improvement whatsoever. As I have a silent migraine- dizziness, pounding, nausea tremors and tension as if my head is constantly in a vice – I am afraid the Amovig is not going to help even though my neoirolist did recommend it.
      Has anyone had any similar experience?
      Thanks

      reply
    • By Nancy Harris Bonk Moderator

      Hi daltal10,

      Thank you for sharing your journey with us. I can tell you it may take more than one injection to see any benefits. Many people start seeing benefits in the first two months and even more so after three months.

      Give it some time, and I’ll keep my fingers crossed!

      Wishing you a low pain day,
      Nancy

      reply
    • By daltal10

      That all this applies to a silent migraine too?

      reply
  • By Nancy Harris Bonk Moderator

    Hi beachbumgirl,

    Great tips – thank you for sharing them with us!!

    Wishing you a low pain day,
    Nancy

    reply
  • By Peggy Artman Moderator

    Hi everyone, this is a good question. I originally started with Aimovig and later switched to Emgality. I think I was on Aimovig about six months and it didn’t make anything worse but there wasn’t enough benefit.

    I have been on Emgality for about 6 months now. I have had lower levels of pain overall. Also, the brain fog I get is much better. Normally people say to give a treatment 3 months before giving up on it, but I seem to respond to medications slower.
    ~ Peggy

    reply