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Medications & Prescription Treatment

Zyprexa

  • By Lynn Voedisch

    Has anyone had a doctor prescribe Zyprexa as an abortive when you get stuck in a migraine cycle? It’s a bi-polar drug used off label at a very low dose. I found it to be miraculous–it worked on re-balancing serotonin.

    My old migraine doctor retired and the new one doesn’t know a thing about it. There used to be samples all over the office, but now, nothing. I known old insurance company got snarky about paying for it, but I’m in a new company now. Wondering how to get my doctor to prescribe it for me.

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  • By Nancy Harris Bonk Moderator

    Hi lynnv,

    I’m afraid Zyprexa won’t abort an attack, but could possibly be used for migraine prevention. Medications that abort migraine attacks include triptans and ergotamines and I can share information on abortives with you here; https://migraine.com/blog/migraine-management-essential-5-abortive-treatment/.

    There are things we can discuss with our doctor when we our migraine pain has gone on too long These include a steroid dose pack and/or an IV infusion.

    It can be frustrating and exhausting when we need to find a new doctor, as many of us have had to find out. If you’re in the market for a new migraine expert, take a look at this information; https://migraine.com/blog/how-are-migraine-specialists-different/ and https://migraine.com/blog/looking-for-a-migraine-specialist/.

    Nancy

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    • By Cgowin

      My neurologist just prescribed Zyprexa for when I get the 4 day migraine I can’t get rid of. I am on migraine maintenance medication daily (Trokendi 225 mg a day). But I still get one, sometimes two migraines a month (they last 3-4 days). The weather is a trigger, as I have allergies and am on medication for that also. I have tried Imitrex, Maxalt, Replax and Zomig, none of those have even come close to even curbing my migraine when it hits. So I am hoping that Zyprexa offers at least some relief. I was glad to read that it worked for someone, and I hope you find someone to get you back on your “Zyprexa path” (for lack of a better term to call it). Best of luck, from a person who empathizes with pain of chronic migraines.

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  • By Lynn Voedisch

    Nancy, it’s a moot subject now as I got another doctor to prescribe it for me. Perhaps “abortive” was the wrong word. Zyprexa can be taken when a migraine seems to be coming back (and I get a lot of those migraine that go into an endless spiral). The Zyprexa stops that, and you can go on with your life.

    My clinic will only give me Decadron once a quarter (something to do with too many steroids causing cataracts). The also prescribe vasoconstrictors to take for several days. And there is a muscle relaxant with another drug that they give me that sometimes works. Zyprexa is for the times when they aren’t going to give me the good stuff. (They are very careful, so I don’t fault them.) I don’t want any IV infusions unless I’m hospitalized and that has to be for the worst sort of stubborn migraines. I was hospitalized in October for migraines that went on one after the other for four weeks!
    Normally, I have plenty of triptans as abortives for regular migraines.

    Also, not sure why you think I’m looking for a new doctor. My doctor is fantastic. Very caring and works WITH me rather than lecturing to me. There was a time I was rudderless, when my old migraine doctor retired. But I found my current one at the same clinic I go to; some other docs there recommended him to me. Just because he didn’t know about Zyprexa doesn’t mean he’s someone I’d leave. In all other regards, he’s a top doctor.
    Maybe I’m not clear when I post things.

    Lynn

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  • By Nancy Harris Bonk Moderator

    Hi 62fuu1,

    I’m sorry you are having a tough time finding medications to help with your migraine attacks. Are you having more than four severe attacks a month? If so it’s time to talk to your doctor about migraine prevention. Let me share our information on this with you: https://migraine.com/blog/migraine-management-essential-4-preventive-treatment/.

    Medications that abort or stop the migraine process are called triptans and include Amerge, Axert, Frova, Imitrex, Maxalt, Relpax and Zomig. It may be worth it to try them all, they each work a bit differently for people. Zyprexa is not a migraine abortive medication.

    Good luck.
    Nancy

    Zyprexa is an antipsychotic medcation, not an abortive. Therefore, it won’t stop the migraine process. Abortive medciations include triptans such as Amerge, Axert, Frova, Imitrex, Maxalt, Replax and Zomig.

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  • By zelepunkin

    Lynn-
    Thank you for sharing your experiences with Zyprexa. I have chronic migraines and have been in an awful cycle for the past for months. I go to a wonderful neurologist (who’s also on the list above) who prescribed me Zyprexa with my Maxalt to help break the cycle. I am hoping that it works! I’ve exhausted my preventative options (depakote, topamax, beta blockers, amitriptyline) and now need regular nerve blocks and infusions. While it’s not standard therapy, I think those of us who are suffering with chronic migraine know that our response to medication changes over time and their is no standard therapy.

    I feel blessed to have a neurologist who listens to me and works with me to find the right plan for ME. Heres a link to one of the research studies done at my Headache Center supporting the use of Zyprexa (http://www.ncbi.nlm.nih.gov/pubmed/12167140).

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  • By Hemicrancont

    Thanks for all your help. My doctor gave me zyprexa as an abortive– he said he has tried it in the past and it worked. Still, I don’t really feel like taking something like that. I’ll let you know if it works. I have a migraine right now, but it’s milder, and the middle of the day and zyprexa is said to make you sleeep.

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  • By bigE

    Went to the ER with bad migraine, the doctor gave me zyprexa and zofran IV. Worked great. The only other thing that worked for me was topiramate, worked great never had a migraine while taking it, but I lost too much weight and they had to take me off. So now when my head starts to hurt I take one or two zyprexa and a zofran. Seems to help. I have a whole drawer full of pills that didn’t.

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  • By RainbowLighthouse

    i took zyprexa as an abortive medication and it gave me severe weight gain so beware. i have tried zimig to no avail. i was on midriff as a teenager and mh doc tells me it is has been discontinued. i would like to try going back on topamax but gently gentle titrated up. this helped as the second time i was Rxed it, i went up a big faster but still as ordered and parent s found me passed out in a chair in a basement while reading. be careful to go up slowly and to always change just ONE MED at a time so you know what is causing what an there will not be any confusion.

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