Ajovy (fremanezumab-vfrm)

Reviewed by: HU Medical Review Board | Last reviewed: May 2023 | Last updated: May 2023

Ajovy™ (fremanezumab-vfrm) is a prescription drug used for the preventative treatment of migraine in adults. Ajovy is a type of drug known as a calcitonin-gene-related peptide (CGRP) blocker.1

What are the ingredients in Ajovy?

The active ingredient in Ajovy is fremanezumab.1

How does Ajovy work?

Ajovy is a monoclonal antibody that targets CGRP. Like antibodies that are created by the body to target specific invaders, monoclonal antibodies are created in a lab to attach to specific proteins.1

Ajovy attaches to the CGRP peptide ligand and blocks it from binding to the receptor. The CGRP protein is involved in vein dilation and the sensory nervous system, both of which are impacted by migraine. Research has found that during a migraine attack, CGRP levels are increased. By blocking the protein’s ability to connect with the receptor, Ajovy may reduce the frequency or severity of migraine attacks.1

What are the possible side effects?

The most common side effects of Ajovy include injection site reactions.1

Ajovy may also cause allergic reactions. These reactions, including itching, rash, and hives, can happen within hours and up to 1 month after receiving Ajovy. Contact your doctor right away if you have the following signs of an allergic reaction:1

  • Swelling of your face, mouth, tongue, or throat
  • Trouble breathing

These are not all the possible side effects of Ajovy. Talk to your doctor about what to expect when taking Ajovy. You also should call your doctor if you have any changes that concern you when taking Ajovy.

Other things to know

Ajovy is given by injection under your skin (subcutaneously). Your doctor will show you or your caregiver how to prepare and inject Ajovy.1

There is not enough data to know if Ajovy is safe to take while pregnant or breastfeeding. Before starting treatment with Ajovy, tell your doctor if you are pregnant, planning to become pregnant, or breastfeeding. They can help you decide if Ajovy is right for you.1

Before beginning treatment for migraine, tell your doctor about all your health conditions and any other drugs, vitamins, or supplements you are taking. This includes over-the-counter drugs.

For more information, read the full prescribing information of Ajovy.

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