Amitriptyline vs Propranolol for migraine

When my husband was experiencing episodic migraines he was prescribed both of these drugs, at different times of course, but unfortunately they didn't work for him. This was partly because of medication he was on for a heart condition. Propranolol didn't react well with his heart medication. As with any medication regimen you have to give it a try and see if it works for you. Some medications are life changers for some and for others they have no beneficial results. Work with your doctor to find the ones that are effective for you. Warmly, Cheryl migraine.com team

Hi- thanks so much for the question. Here are some resources we have on this very topic- articles from people just like you who have posted on these meds and the combination of them, in the past- be sure to read the comments section the follows as other community members ring in with their experiences as well: https://migraine.com/stories/preventative-migraine-meds-a-new-part-to-my-old-problem
https://migraine.com/stories/side-effects-amitriptyline

https://migraine.com/search?s=propanolol
https://migraine.com/search?s=amitriptyline
I hope you'll be able to find some useful information in these pieces. Please let us know what other questions you have- we are here for you. Warmly- Holly (migraine.com team).

hi I’ve been on propananol for years. Not had any problems with it

Hi=I tried both but neither helped me. Pre sumatriptan the only thing that ever helped me with my migraines and clusters was Cafergot. I could only take it about 5 days before I got toxic. Toes and feet would start cramping. Calcium channel blockers- verapamil or now amlodipine plus sumatriptan have really helped me. You can really sleep the first few days on Amitriptyline.