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Immflamation issues with imitrex

Has anyone had any issues with imitrex and it making your muscles and joints hurt. I was having a problem with my lateral foot and when I took imitrex it made my foot hurt 3x more. I’ve always had issues with it hurting my muscles and joints but it was really surprising it effected my foot that way. anyone else experience these side effects.

  1. Been on imitrex for 25 years? Hadn’t experienced joint pain until this last year. Now a regular thing, I feel it’s a blood flow issue but not sure.

    1. Works very well for my headaches, the only thing I’ve found that does.

    2. That's wonderful. So many people spend years trying to find something that works. Let us know if you discuss the joint pain issue with your doctor. We'd be interested in learning about this issue. Warmly- Holly -migraine.com team.

  2. My doctors won’t tell me why this is happening. I’m in horrible pain when I take it. My migraine goes away, but severe muscle and joint pain plus burning skin.

    1. I use imitrex injections for my migraines. I have not experienced joint issues when taking it. Despite this, I do experience a burning sensation. I become very sensitive to anything touching my skin.
      Have you considered trying a different abortive medication? It may help to know if your symptoms are a side effect to the medication or a symptom of your migraines. Best wishes - Amanda W (Team Member)


    2. I'm so sorry you are experiencing this pain when taking sumatriptan. I'm not sure which delivery method you are using. I'm unable to take the pill form of any triptan because of 'triptan sensation', a feeling of unease, tightness in my chest/jaw. My doctor suggested I try the nasal spray and viola! I don't have any problems with it. I wonder if discussing taking another form of this triptan would be beneficial.
      The link has interesting information that may explain things a bit.
      The thing about migraine and headache disease is we don't understand a lot of what we experience.
      Please keep me posted on how you are doing, Nancy Harris Bonk, Patient Leader/Moderator Migraine.com Team


  3. I am very susceptible to this type of pain when taking medication, especially with steroids and antibiotics, but I haven't had issues with Imitrex other than it not working so well on my migraines. I was reading an article/study from 2000 that muscle and joint pain can result - as a short-lived side effect - from taking Imitrex. https://pubmed.ncbi.nlm.nih.gov/10817445/#:~:text=Sumatriptan%20succinate%20(Imitrex)%20is%20a,and%20muscle%20aches%20and%20pains. The best thing to do is discuss this again with your doctor and as Amanda stated see if there is another medication that would work better for you. I am using Maxalt now instead of Imitrex and it seems to help me better. Unfortunately, you've got to find what works best through trial and error, which takes time. Rebecca (comm advc)

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