Reyvow (lasmiditan)

Reviewed by: HU Medical Review Board | Reviewed March 2022

Reyvow®(lasmiditan) is a prescription drug used for the acute treatment (also known as abortive or rescue medication) of migraine attacks with or without aura in adults.1

Reyvow is a type of drug known as a ditan. Ditans may be an option for people who cannot take triptans or do not respond to triptans or other migraine therapies.1

What are the ingredients in Reyvow?

The active ingredient in Reyvow is lasmiditan.1

How does Reyvow work?

The exact ways that Reyvow works aren’t known. But research shows that Reyvow binds to 5-HT1F receptors in the brain. Experts believe that by binding to these receptors, Reyvow stops pain-signaling pathways.1

What are the possible side effects?

The most common side effects of Reyvow include:1

  • Dizziness
  • Sleepiness
  • Numbness, tingling

These are not all the possible side effects of Reyvow. Talk to your doctor about what to expect when taking Reyvow. You also should call your doctor if you have any changes that concern you when taking Reyvow.

Other things to know

Reyvow is a federally controlled substance because it contains lasmiditan, which can be abused. Keep Reyvow in a safe place. Never give your Reyvow to anyone else, because it may harm them. Selling or giving away Reyvow is against the law.1

Do not drive or operate machinery for at least 8 hours after you take Reyvow, even if you feel well enough. Do not take Reyvow if you cannot wait at least 8 hours between taking the medicine and driving or operating machinery.1

Before starting treatment with Revow, tell your doctor if you have:1

  • Liver problems
  • High blood pressure
  • A low heart rate
  • An allergy to lasmiditan
  • A substance-use disorder

There is not enough data to know if Reyvow is safe to take while pregnant. Before starting treatment with Reyvow, tell your doctor if you are pregnant or planning to become pregnant. They can help you decide if Reyvow is right for you.1

Reyvow can interact with other medicines and cause side effects. Before starting treatment with Reyvow, tell your doctor if you take:1

  • Propranolol or other medicines that can lower your heart rate
  • Any medicines that can increase your blood pressure
  • Any medicines that make you sleepy
  • Anti-depressant medicines called:
    • Selective serotonin reuptake inhibitors (SSRIs)
    • Serotonin-norepinephrine reuptake inhibitors (SNRIs)
    • Tricyclic anti-depressants (TCAs)
    • Monoamine oxidase inhibitors (MAOIs)

Before beginning treatment for migraine, tell your doctor about all your health conditions and any other drugs, vitamins, or supplements you are taking. This includes over-the-counter drugs.

For more information, read the full prescribing information of Reyvow.