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Frova® (Frovatriptan Succinate)

Frova® (frovatriptan succinate) is a selective 5-HT1B/1D receptor agonist (triptan) indicated for the acute treatment of migraine, with or without aura, in adults who have a clear migraine diagnosis. It is taken by mouth for the relief of migraine severity, from moderate or severe pain to mild or no pain.

Frova is generally well tolerated and is usually effective within 2 hours. It is intended to reduce acute migraine symptoms, as it will only treat a migraine that has already begun. It should not to be used as a prophylactic therapy to prevent the onset of migraine.

Overuse of acute migraine drugs can cause medication overuse headaches. Overuse is considered dosing on more than 4 days per month. Symptoms of overuse may need to be treated and detoxification from migraine medications may be required.

What are the ingredients in Frova?

The active ingredient in Frova is frovatriptan succinate.

How does Frova work?

Frova works by binding with 5-HT1B/1D receptors on blood vessels in the brain. It narrows the blood vessels (constriction) in the brainstem. It also reduces the inflammatory substances in the body that can trigger head pain, nausea, sensitivity to light and sound, and other migraine symptoms. Frova works best if it is taken as soon as migraine symptoms appear.

What are the possible side effects of Frova?

Many clinical trials evaluated the safety and efficacy of Frova. The most common side effects experienced by those taking Frova include:

  • Pain or tight feeling in the chest, throat, jaw, or neck
  • Skeletal pain in joints or bones
  • Feeling weak, drowsy, or tired
  • Pressure or heavy feeling in any part of your body
  • Numbness or tingling in the fingers and toes (paresthesia)
  • Feeling hot or cold in the extremities
  • Flushing (warm red skin or face)
  • Dizziness
  • Nausea or indigestion
  • Headache (other than a migraine headache)

This is not an exhaustive list of all potential side effects of Frova. For more information, consult your doctor or healthcare provider. If you notice any new or worsening side effects when taking Frova, contact your doctor or healthcare provider immediately.

Things to note about Frova

Frova tablets come in a single strength of 2.5 mg. Before starting Frova talk with your doctor if you:

  • Have a history of hypersensitivity to frovatriptan succinate
  • Have a history of coronary artery disease (CAD), angina or heart attacks
  • Have a history of high blood pressure or high cholesterol
  • Have a history of hemiplegic or basilar migraine
  • Have a history of stroke, transient ischemic attacks (TIAs), or circulatory problems
  • Have a history of ischemic bowel disease
  • Are a female who has gone through menopause
  • Are a man over 40
  • Are overweight, smoke, or have diabetes
  • Have taken ergot-containing medication or triptans within the 24 hours prior to migraine
  • Have taken a MAO-A inhibitor within 2 weeks prior to your migraine
  • Take anti-depressant medicines including selective serotonin reuptake inhibitors (SSRIs), serotonin norepinephrine reuptake inhibitors (SNRIs), or tricyclic antidepressants (TCAs)
  • Have severe hepatic (liver) impairment
  • Are pregnant or planning to get pregnant, as there is limited information on the use of Frova in pregnancy. It should be used only if the potential benefit of Frova therapy exceeds risk to the fetus.

Individuals with the above conditions should be monitored closely while taking Frova.

If there is no response to the first migraine attack treated with Frova, a physician should reconsider the migraine diagnosis prior to using the medication in any subsequent attacks.

A cardiovascular evaluation should be performed on patients who have never taken a triptan medication but who have multiple cardiovascular risk factors (e.g., increased age, diabetes, hypertension, smoking, obesity, strong family history of CAD) before starting Frova. For those with a cardiac history, the first dose of Frova should be administered in a medically supervised setting, and an electrocardiogram (ECG) should be performed immediately following the dose.

Dosing information

Frova tablets are taken by mouth with water or other liquids. The recommended dose of Frova is 2.5 mg. If only partial migraine relief is attained or symptoms returns quickly, a second dose may be taken 2 hours after the first. The maximum dosage in a 24-hour period is 3 tablets, for a total of 7.5 mg.

Keep track of when you have migraine and when you take Frova so you can monitor its effectiveness, and communicate with your doctor about how the medication is working for you.

Before taking Frova make sure to tell your doctor about all the medicines you take, including prescription and nonprescription, vitamins, and herbal supplements. Frova and other medicines may impact each other, causing side effects.

Because Frova can cause dizziness, weakness, and drowsiness, do not drive a car, use machinery, or do anything requiring you to be fully alert when taking this medication.

For additional details, read the full prescribing information of Frova.

Written by: Linda Saxl Minton | Last reviewed: August 2019
  1. FROVA prescribing information available at: Accessed 4/30/18.