Nurtec® (rimegepant)

Reviewed by: HU Medical Review Board | Reviewed April 2022 | Last updated: April 2023

Editor’s Note: Nurtec® ODT 75 mg orally disintegrating tablets were recalled on March 16, 2023, because the packaging is not child-resistant. If swallowed by young children, this drug poses a risk of poisoning. Anyone using this drug should store the drug out of sight and reach of children and contact Pfizer at 800-879-3477 for a free child-resistant pouch to store the medicine. Once Nurtec is stored safely, you may continue the use of the drug as directed by your doctor.

Nurtec® (rimegepant) is approved for the acute treatment of migraine with or without aura and preventive treatment of episodic migraine in adults. Nurtec is an orally dissolving tablet taken by mouth. It disintegrates quickly, allowing it to dissolve and act fast in the body.

What are the ingredients in Nurtec?

The active ingredient in Nurtec is rimegepant. Rimegepant is a calcitonin gene-related peptide (CGRP) receptor antagonist. It belongs to a class of drugs called gepants.

How does Nurtec work?

Nurtec aims to quickly reduce pain by blocking the action of CGRP. CGRP is a protein found in the brain and nerves of the head and neck. CGRP may increase pain. People with migraine often have high levels of CGRP before and during an attack, which may be why they experience severe symptoms. By blocking the action of CGRP in the brain and some of these nerves (called the trigeminal system), migraine pain may be reduced.

What are the possible side effects of Nurtec?

The most common side effect reported with Nurtec is nausea. However, other side effects may be possible. Talk with your doctor about any other side effects you experience while taking Nurtec.

Things to know about Nurtec

Very rarely, some people may have an allergic reaction to Nurtec. Signs of an allergic reaction include rash, shortness of breath, and swelling of the tongue, mouth, or throat. If you think you may be experiencing an allergic reaction to Nurtec, contact your doctor as soon as possible.

Nurtec may interact with other drugs. Before starting Nurtec, talk with your doctor about all other medicines you take. This includes over-the-counter drugs, vitamins, and supplements.

Nurtec may impact people with liver or kidney issues differently. Tell your doctor if you have a history of liver or kidney issues before starting Nurtec to make sure it is safe for you to take.

It is not known if Nurtec is safe to use in kids. It is also not known how Nurtec might affect an unborn baby. If you or your partner could become pregnant while taking Nurtec, talk with your doctor to determine if Nurtec is right for your situation. If you are breastfeeding or planning to breastfeed while taking Nurtec, talk with your doctor as well.

For more information, read the full prescribing information of Nurtec.