Body doesn't seem to metabolize medicine

My story is long and very similar to so many of you.

My biggest concern and source of frustration in trying to treat my migraines is the horrible side affects I experience from everything I have ever tried. One example is Corgard. I took it from November to April and suffered terrible depression, anxiety, severe muscles/joint pain, extreme fatigue and shortness of breath. I got about 50% relief from my daily HA's and migraines so I really wanted it to work. When I had Botox injections I again felt extreme fatigue, anxiety and depression from it. I couldn't get out of bed for two days and felt poisoned. I felt very unwell for three months until it finally wore off. I take Relpax for migraines and it seems to work best with Lorazepam. Again, I can only take a tiny piece of Lorazepam or it makes me feel fatigued, dull and toxic for another 24 hours. Making it very hard to do my job!

A psychiatrist explained something about genome testing and my liver not metabolizing medications. I desperately need a prophylactic but nothing is tolerable. Does anyone have any feedback or can relate? When I mention this to my migraine specialist he nods but I don't get confirmation. Anyone else experience this?

I'm not looking for medical advise just someone who can relate and share their experience. Thank you.

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