Expert Answer: Blood Platelet Count & Migraines

Question: What does blood platelet count have to do with Migraine?

Platelets are indeed involved in the development of migraine. They tend to become sticky and release serotonin which is intimately involved in the migraine process. Aspirin, among other effects, prevents platelets from becoming sticky and that is how, at least in part, it is thought to treat and prevent migraine headaches.

The actual number of platelets or platelet count is also important to know because people who have too many platelets (a condition called thrombocytosis) are more likely to develop headaches. Headache is one of the most common neurological symptoms of thrombocytosis. Effective treatment to reduce the excessive number of platelets will usually improve headaches as well.

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