Expert Answer: Blood Platelet Count & Migraines
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Question: What does blood platelet count have to do with Migraines?

Platelets are indeed involved in the development of migraines. They tend to become sticky and release serotonin which is intimately involved in the migraine process. Aspirin, among other effects, prevents platelets from becoming sticky and that is how, at least in part, it is thought to treat and prevent migraine headaches. The actual number of platelets, or platelet count is also important to know because people who have too many platelets (a condition called thrombocytosis) are more likely to develop headaches. Actually, headache is one of the most common neurological symptoms of thrombocytosis. Effective treatment to reduce the excessive number of platelets will usually improve headaches as well.

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