The thing with Midrin is it was grandfathered in the FDA clinical trials. This essentially means that manufacturers make it, then they don’t, then they make it again. If you have a “compounding” pharmacy near you, you can actually have your doctor order the different ingredients, in the amounts needed, and the compounding pharmacy will make it for you. It doesn’t seem to be too much to ask for, something that doesn’t aggravate your colitis, but Heck, they can’t even give us a medication that works for migraines! So unfortunately for everyone, it’s always trial and error. What works for one, will not necessarily work for the masses.