I have been in a study for CGRP (Amgen sponsored) at the Jefferson Headache Center in Philadelphia under Dr. Silberstein. For the past 4 years I have been receiving the drug. I can't say enough, it has changed my life. I was getting at least 1 migraine/week. I now get less than 1 /month. It's not fool proof, but the frequency has significantly dropped and there have been no side effects for me. I would encourage anyone with chronic migraines to see you headache specialist about this ground-breaking drug.