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Vyepti Infusions and Migraines

I have been getting Vyepti infusions (soon will be my 4th) and this month especially I have gotten MANY migraines and more painful ones. I started out so happy because I had fewer migraines and the ones I had were of lesser intensity. The third time there were more, then this month much more. I am so depressed. Aimovig and Adjovy provided little relief. I was so happy with Vyepti at first.

  1. I'm sorry to hear that it seems like the Vyepti is losing its effectiveness. I know how frustrating it can be when our meds stop working as intended. Have you discussed these changes with your doctor? I wonder if there are any adjustments to the medication that may be possible. Fingers crossed they will be able to make some adjustments, and that you'll start getting the much-needed relief you deserve. - Cody (Team Member)

    1. I go in June to see my Migraine Specialist and I will share what is happening. Thank you for your concern!

      1. Oh no! I'm so sorry to hear this has happened! We have heard of this happening with some of the CGRPs. Glad you have an appointment coming up in June (though I'm sure that can't happen soon enough with this uptick in attack frequency). I've had migraine for many decades and have found that the best chances I have at relief are when my doctor and I work to cobble various treatments together. I have rarely had success with just one approach. For instance, I get Botox injections and also take Emgality. Either one of those on their own doesn't seem to help much, but together I get better relief. Also wondering if you've yet to try Nurtec (both a preventative and rescue) or Ubrevly? There are a lot of new treatments coming out these days. All this said, I know what a disappointment it is to watch the efficacy of a treatment that was successful disintegrate right in front of you. It's really disheartening! We are here for you and in this with you- every step of the way. We're so glad you're with us. Let us know how that appointment goes in June. Thinking of you. Warmly- Holly -migraine.com team.

    2. Yes, Ubrelvy is wonderful! I am hoping to maybe try Quilipta now that it's oked for chronic migraines.


      1. Good to hear Ubrelvy is beneficial. I can tell you Qulipta and Nurtec have both been approved for chronic migraine. We have more information on this here; https://migraine.com/living-migraine/trying-oral-cgrp-preventives.
        I hope you keep us posted on your next step and I'm sending you pain free wishes, Nancy Harris Bonk, Patient Leader/Moderator Migraine.com Team

    3. Thank you! I will keep you posted on my quest!

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