Imitrex® (Sumatriptan Succinate)

Reviewed by: HU Medical Review Board | Reviewed March 2022 | Last updated: June 2022

Imitrex® (sumatriptan succinate) is a selective 5-HT1B/1D receptor agonist (triptan) indicated for the acute treatment of migraine, with or without aura, in adults who have a clear migraine diagnosis. It is taken by mouth for the relief of migraine severity, from moderate or severe pain to mild or no pain.

Imitrex generally works within 2 hours. It is intended to reduce migraine symptoms, as it will only treat a migraine that has already begun. It should not to be used as a prophylactic therapy to prevent the onset of migraine.

Overuse of acute migraine drugs can cause medication overuse headaches. Overuse is considered dosing on more than 10 days per month for 3 months or longer. Symptoms of overuse may need to be treated and detoxification from migraine medications may be required.

What is the main ingredient in Imitrex?

The active ingredient in Imitrex is sumatriptan succinate.

How does Imitrex work for migraine?

Imitrex works by binding with 5-HT1B/1D receptors on blood vessels in the brain. It narrows the blood vessels (constriction) in the brainstem. It also reduces the inflammatory substances in the body that can trigger head pain, nausea, sensitivity to light and sensitivity to sound, and other migraine symptoms. Imitrex works best if it is taken as soon as migraine symptoms appear.

What are the possible side effects of Imitrex?

Many clinical trials evaluated the safety and efficacy of Imitrex. The most common side effects experienced by those taking Imitrex include:

  • Pain or tight feeling in the chest, throat, jaw, or neck
  • Feeling weak, drowsy, or tired
  • Pressure or heavy feeling in any part of your body
  • Numbness or tingling in the fingers and toes
  • Feeling hot or cold in the extremities

This is not an exhaustive list of all potential side effects of Imitrex. For more information, consult your doctor or healthcare provider. If you notice any new or worsening side effects when taking Imitrex, contact your doctor or healthcare provider immediately.

Things to note about Imitrex

Before starting Imitrex talk with your doctor if you:

  • Have a history of hypersensitivity to sumatriptan succinate
  • Have a history of coronary artery disease (CAD), angina or heart attacks
  • Have a history of high blood pressure or high cholesterol
  • Have a history of hemiplegic or basilar migraine
  • Have a history of stroke, transient ischemic attacks (TIAs), or circulatory problems
  • Have a history of ischemic bowel disease
  • Are a female who has gone through menopause
  • Are a man over 40
  • Are overweight, smoke, or have diabetes
  • Have taken ergot-containing medication or other triptans within the 24 hours prior to migraine
  • Have taken a MAO-A inhibitor within 2 weeks prior to your migraine
  • Take anti-depressant medicines including selective serotonin reuptake inhibitors (SSRIs), serotonin norepinephrine reuptake inhibitors (SNRIs), or tricyclic antidepressants (TCAs)
  • Have severe hepatic (liver) impairment
  • Have severe renal (kidney) problems
  • Are pregnant or planning to get pregnant, as there is limited information on the use of Imitrex in pregnancy. It should be used only if the potential benefit of Imitrex therapy exceeds risk to the fetus.

Individuals with the above conditions should be monitored closely while taking Imitrex.

If there is no response to the first migraine attack treated with the Imitrex, a physician should reconsider the migraine diagnosis prior to using the medication in any subsequent attacks.

A cardiovascular evaluation should be performed on patients who have never taken a triptan medication but who have multiple cardiovascular risk factors (e.g., increased age, diabetes, hypertension, smoking, obesity, strong family history of CAD) before starting Imitrex. For those with a cardiac history, the first dose of Imitrex should be administered in a medically supervised setting and an electrocardiogram (ECG) should be performed immediately following the dose.

Keep track of when you have migraine and when you take Imitrex so you can monitor its effectiveness, and communicate with your doctor about how the medication is working for you.

You should begin no medication or supplement without first checking with your health care provider and should let them know of any other prescriptions, OTCs, and herbals you are taking to ensure there are no interactions.

Because Imitrex can cause dizziness, weakness, and drowsiness, do not drive a car, use machinery, or do anything requiring you to be fully alert when taking this medication.

For additional details, read the full prescribing information of Imitrex.

By providing your email address, you are agreeing to our privacy policy.