Tosymra® (sumatriptan)

Reviewed by: HU Medical Review Board | Last reviewed: November 2020

Tosymra (sumatriptan nasal spray) is used as an acute treatment of migraine with or without aura in adults.1

What is the active ingredient in Tosymra?

The active ingredient in Tosymra is sumatriptan, a selective 5-HT1B/1D receptor agonist.2

How does Tosymra work?

While there are currently other sumatriptan nasal sprays available on the market, Tosymra has a different delivery method. An excipient is an inactive substance that works as a vehicle to deliver medicine and allow the body to absorb the drug.1

The inactive ingredient in Tosymra delivers the drug quickly and efficiently, with people absorbing as much drug as they would if they were to have a 4 mg sumatriptan injection. This high absorption rate means that Tosymra can work quicker and provide faster relief from migraine.2

What are the possible side effects of Tosymra?

The most common side effects of Tosmyra include:1,2

  • Tingling
  • Feeling warm or hot
  • Dizziness
  • Burning feeling
  • Feelings of heaviness, pressure, numbness, or tightness
  • Flushing
  • Feeling tightness or pressure in the chest
  • Weakness or drowsiness
  • Abnormal taste
  • Throat irritation

These are not all the possible side effects of Tosymra. Talk to your doctor about what to expect or if you experience any changes that worry you.

Things to know about Tosymra

Tosymra may cause serious heart-related side effects (including heart attacks), in some people. Anyone at risk for heart disease (including people who are overweight, have high cholesterol or diabetes, have a family history of heart disease, or those who smoke) should have routine heart tests and be cleared before taking Tosymra.1

Tosymra should not be taken with:2

  • Drugs containing ergot
  • Monoamine oxidase-A (MOA) inhibitors
  • Other 5-HT1 agonists

Tosymra may also cause a condition known as serotonin syndrome, especially in people who are also taking certain types of antidepressants. If you notice mental changes such as hallucination or agitation, changes in blood pressure or heartbeat, fevers, or muscle issues such as trouble walking, call your doctor right away.1

The safety of using Tosymra in people under age 18 or over age 65 has not been established. It appears to be safe to use when pregnant.2

Before taking Tosymra, tell your doctor about any other drugs, vitamins, or supplements you are taking. This includes over-the-counter drugs.

For more information, read the full prescribing information of Tosymra.

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