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Ubrelvy (ubrogepant)

Reviewed by: HU Medical Review Board | Last reviewed: May 2023

Ubrelvy™ (ubrogepant) is approved for the acute treatment of migraine in adults. It can be used for the treatment of migraine with or without aura.1

Ubrelvy belongs to a class of drugs called gepants. A gepant is a calcitonin gene-related peptide (CGRP) receptor antagonist. Ubrelvy is taken by mouth and may help quickly block pain signaling in the brain.1

What are the ingredients in Ubrelvy?

The main ingredient in Ubrelvy is ubrogepant.1

How does Ubrelvy work?

Ubrelvy is a CGRP receptor antagonist. CGRP is a protein that is often found in the brain and sensory nerves of the head and neck. These sensory nerves are a part of the trigeminal system and may be involved in the development of migraine. CGRP plays a role in pain signaling and our body’s perception of pain.

During a migraine attack, a person might have high amounts of CGRP. This could impact their pain levels. A gepant is a small molecule designed to stop the action of CGRP. By blocking CGRP, pain perception may be reduced.

Ubrelvy is the first anti-CGRP drug designed for immediate use. Other CGRP therapies are injected into the body and are used for long-term, preventative treatment. However, Ubrelvy can be used to stop a migraine attack. It is not used for preventative treatment of migraine.1

What are the possible side effects?

The most common side effects experienced with Ubrelvy include:1

  • Nausea
  • Drowsiness or sleepiness

These are not all the possible side effects of Ubrelvy. Talk to your doctor about what to expect when taking Ubrelvy. You also should call your doctor if you have any changes that concern you when taking Ubrelvy.

Other things to know

Before starting treatment with Ubrelvy, tell your doctor if you have:1

  • Liver problems
  • Kidney problems

There is not enough data to know if Ubrelvy is safe to take while pregnant or breastfeeding. Before starting treatment with Ubrelvy, tell your doctor if you are pregnant, planning to become pregnant, or breastfeeding. They can help you decide if Ubrelvy is right for you.1

Ubrelvy may interact with other medicines. Before staring treatment with Ubrelvy, tell your doctor if you take any of the following medicines:1

  • Barbiturates
  • Carvedilol
  • Ciprofloxacin
  • Curcumin
  • Cyclosporine
  • Eltrombopag
  • Fluconazole
  • Fluvoxamine
  • Phenytoin
  • Quinidine
  • Rifampin
  • St. John’s Wort
  • Verapamil

Before beginning treatment for migraine, tell your doctor about all your health conditions and any other drugs,

For more information, read the full prescribing information of Ubrelvy.

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