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CGRPs (calcitonin-gene-related peptide)

Any one with Crohn's and ulcerative colitis tried CGRPs or input ?

  • By chantrelle

    Hi,

    I will be starting Aimovig in December, despite being very inconfortable with trying any anti CGRP migraine treatment. I have ulcerative colitis and it is mainly what’s adding to my worries of trying the anti CGRP treatment.

    But since I have an average of 27 days of migraines / month and that the Botox has mostly only reduce the intensity, I fell I don’t have much choice.

    I would really like hear about any one who have tried anti CGRP that also have ulcerative colitis (or Crohn’s).

    Thank so much for any in put,

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  • By Nancy Harris Bonk Moderator

    Hi chantrelle,

    That’s a great question, thank you for asking it. I don’t have this, but know others who do. Hopefully they’ll be along shortly to share their experiences with you.

    Best,
    Nancy

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  • By chantrelle

    Here is one of the articles I read that made me worried about taking anti CGRP while suffering from an chronic inflammatory bowel disease.

    http://practicalneurology.com/2018/02/calcitonin-gene-related-peptide-monoclonal-antibodies/

    It states that : “ In animal models administered CGRP antibodies, there was mucosal damage, suggesting that CGRP antibodies could contribute to loss of gastrointestinal mucosal integrity and predispose patients to inflammatory bowel disease.”

    I do not find any where any advice for patient who already have an chronic inflammatory bowel disease.

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  • By Nancy Harris Bonk Moderator

    Hi chantrelle,

    Thank you for sharing that. I just read the article, very interesting. I haven’t seen any suggestions for people with inflammatory bowel disease either. I will keep my eyes open and see what else I can find out.

    Nancy

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