Botox: Potentially very harmful and IMO should not be used by older people at all. Side effects are insidious, slow to develop, and for me, started at about 9 months after my first treatment. Symptoms were a form of cognitive impairment and dementia on the same spectrum that maps to Alzheimer's symptoms. Recovery was very slow, on the order of more than a year, but not complete even then. There is now laboratory evidence that the botox protein toxin can migrate into brain tissue and disable cholinergic CNS neurons. My suggestion is that older people should not even try it. It is not worth the risk. Older people should not use *any* drugs known to have anticholinergic activity, for any reason. BEWARE.