Is there a correlation between the menstrual cycle and migraines? I suffered from painful irregular cycles as a teen but it got a little better after I had a baby. When I first had my migraine attack, 8 years ago, it was after an abnormally long cycle. Now, when I about to get my “monthly visitor”, my migraine starts and my emergency Imitrex doesn’t work. Is there a connection, or am I just reaching? The unpredictability of the migraine attacks is really hard for me. Especially because once it starts, it lasts for 72 hours.