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Ubrelvy™ (ubrogepant)

Ubrelvy™ (ubrogepant) is approved for the acute treatment of migraine in adults. It can be used for the treatment of migraine with or without aura.1

It belongs to a class of drugs called gepants. A gepant is a calcitonin gene-related peptide (CGRP) receptor antagonist. Ubrelvy is taken by mouth and may help quickly block pain signaling in the brain.1

What are the ingredients in Ubrelvy?

The main ingredient in Ubrelvy is ubrogepant.1

How does Ubrelvy work?

Ubrelvy is a CGRP receptor antagonist. CGRP is a protein that is often found in the brain and sensory nerves of the head and neck. These sensory nerves are a part of the trigeminal system and may be involved in the development of migraine. CGRP plays a role in pain signaling and our body’s perception of pain.

During a migraine attack, a person might have high amounts of CGRP. This could impact their pain levels. A gepant is a small molecule designed to stop the action of CGRP. By blocking CGRP, pain perception may be reduced.

Because it is taken orally, its effects begin quickly. Ubrelvy is the first anti-CGRP medication designed for immediate use. Other CGRP therapies are injected into the body and are used for long-term, preventative treatment. However, Ubrelvy can be used to stop a migraine attack. It is not used for preventative treatment of migraine.1

What are the possible side effects of Ubrelvy?

The most common side effects experienced with Ubrelvy include:

  • Nausea
  • Drowsiness or sleepiness1

Things to know about Ubrelvy

Ubrelvy cannot be taken with certain medications. Before starting Ubrelvy, tell your doctor about any medications you are taking. This includes over the counter drugs, vitamins, or other supplements. It is especially important to tell your doctor if you are taking one of the following:

  • Ketoconazole, itraconazole, or fluconazole
  • Clarithromycin
  • Verapamil
  • Phenytoin
  • Carvedilol
  • Cyclosporine
  • Barbiturates
  • Ciprofloxacin
  • Rifampin
  • Curcumin
  • St. John’s Wort
  • Fluvoxamine
  • Quinidine
  • Eltrombopag1

Ubrelvy may cause harm to a developing fetus and should not be taken by pregnant women. Additionally, children and people with end-stage renal disease should not take Ubrelvy.

Before starting Ubrelvy, tell your doctor if you:

  • Have a history of liver problems
  • Have a history of kidney problems
  • Are planning to become pregnant or are currently pregnant
  • Are planning to breastfeed or are currently breastfeeding1

As mentioned, Ubrelvy is used only for the acute (abortive) treatment of migraine. It is not meant to be used long-term for migraine prevention.1

Dosing information

Ubrelvy comes in tablet form and is taken by mouth. It can be taken with or without food. Tablets are 50 mg or 100 mg each. After 2 hours, a second dose may be taken if needed. Your doctor will help determine which dose is right for you and how often you should be taking it. No more than 200 mg of Ubrelvy should be taken in one day. If you take too much Ubrelvy, call your doctor immediately. A person’s dose of Ubrelvy may need to be adjusted if they have liver or kidney issues.

For more information, read the full prescribing information of Ubrelvy.

Written by: Casey Hribar | Last reviewed: January 2020
  1. Ubrelvy Prescribing Information. Allergan USA, Inc. Available at: Accessed 1/4/2020.