I thought I'd share a good experience with 5HTP 400mg daily, taken in two 200mg doses.
Also, upon an attack a combo of 200mg of it ,accompanied by NSAIDs creates a similar effect to Treximet.
Hope this helps.
November 2, 2014
Did you work up to that dose gradually or did you start off that high? Most herbalists and naturopaths recommend starting 5-HTP at 50 mg and gradually working up. Just like prescription SSRIs, 5-HTP can cause nausea when titrated too rapidly.
I used to recommend it to clients with depression who preferred to try supplements before starting SSRIs. I always instructed them to start at 50 mg and increase by 50 mg every 5-7 days until reaching a max of 200 mg and to stop increasing the dose if they experienced nausea. A few were able to tolerate a higher dose, but most stopped at 200 mg per day.
The theory behind why 5-HTP can help migraine is sound, but little research has been done proving its effectiveness. It is good to hear that it helps you. I would just urge caution and suggest much slower titration to reduce the risk of nausea and vomiting.