I've been fighting with migraines (with aura) since I was a little kid, I believe around 10 years old. As an adult now pushing 40, I've been medicated with amitriptyline (which dried me out horribly), nortriptyline (also dried me out and lost effectiveness), topirimate (which was an absolutely cognitive disaster), and, most recently Aimovig. With each one I also had triptans for once the migraines started, although I never really had much relief with them. Prior to this year, I found that taking 800 mg of Ibuprofen worked to control 95% of the pain after the aura and go on with life, although I couldn't do this too much at the risk of liver damage.
Anyway, I started on Aimovig 70 mg earlier this year after I started having a pile of migraines with aura again, sometimes three aura events in a day and numerous days in a row. Having multiple in a day only started in late 2021. After starting on Aimovig and being on it for about a month, the migraines just stopped altogether... but only for about three months. After that, I started getting groups of migraines again and my dosage was increased to the 140 mg size. Shortly after the dose increase, the migraines seemed to completely stop again, giving me some hope, but this only lasted about two months before I just started getting them again, and I've now had three migraines in the last three days. Unfortunately, it also seems like the severity of them is now significantly worse than before Aimovig such that the supplementary Ibuprofen and triptans don't seem to barely touch the pain.
So, I'm curious - has anyone had Aimovig work well, but only for short period of time before resistance (or antibodies?) built up? This is getting very concerning as I can't work properly through the frequent migraine pain, and the impending possibility of a migraine right around the corner terrorizes me. I was referred to a neurologist about a year ago, but, being that we're in Canada, there's no indication of when I might actually get to see one 🙁