Has anyone had positive or negative experiences with Effexor? After crossing into chronic migraine land last summer, I started struggling also with depression. My migraine specialist suggested Effexor. I titrated up slowly, and had no migraines at all weeks 3 and 4 😀 Then, at the same dose, I developed a near-constant migraine that has lasted almost two weeks 🙁 I am sure it is the Effexor, as I have never experienced anything like this before. Despite the near-constant migraine, the pain is perhaps more mild than usual. Do I stick with it at the dose I am at now, increase the dose (my specialist gave me the option of doing this), or decrease and go off of it? There seem to be advantages to each approach. My doctor is leaving it up to me. Just wondering if others had experienced the same thing and if they eventually worked through it.