Have you tried monoclonal antibodies? How did it go for you?
Did it reduce the days of migraine? I have tried almost every medication so far and I am stil struggling with my headaches, specially because I am a young doctor with a small child and I am still doing my residency. I feel like patients with migraine are misunderstood and we are put on many different things (prophylactic meds and crises meds) and we have to decide if they work or not. I've never felt so bad about the impact my migraines have in my life and it has affected all areas (personal, professional, psychological). Today I feel particularly down because I couldn't go to work. I started yesterday with a migraine and my daughter kept waking up during the night. I was drained and just couldn't wake up and go to work. My head hurts and I just want to rest. I've tried Rimegepant (for acute attacks and Botox for prophylaxis, but the second treatment didn't work. I still have 2-3 migraine crisis per week. I'm also going through a burnout. So everything is interconnected, but I'm trying no to put my life on hold. I have too much on my plate, but I just hope I can reduce the number of migraines. My hospital has the best neurologists, but still I feel like they just don't care. It's just meds+meds... I am going to be put on monoclonal antibodies. I am afraid, because it's the last line of treatment, but I feel like I can't live like this anymore.
Hi
, while you're waiting for feedback from the community, I thought I would share this list of articles that you might find helpful: https://migraine.com/search?s=monoclonal%20antibodies - Warmly, Donna (team member) 
Thank you for reaching out and sharing your experience with us. I understand and hear how frustrating it is to live with migraine disease, we're here for you. Let me see what information I can give you that may help!The first thing that comes to mind is don't lose hope! It may feel like you have tried everything out that available for managing migraine disease, but that may not truly be the case! There are over 100 medications, supplements, devices, complementary therapies and lifestyle modifications that can be used to manage migraine disease and most of us are on a combination of these, I sure am.
https://migraine.com/blog/migraine-preventives-start
Another thought is it may be time to reach out to a doctor who is a true expert in treating migraine and headache. General neurologists may be fine doctors but have a hard time being experts in one area because they treat many conditions such as stroke, epilepsy, multiple sclerosis, Parkinson's and more. A true migraine/headache disease doctor treats migraine and headache all day, every day. These doctors have additional certification not all general neurologists Here is more information on how these doctors are different and how to find one;
https://migraine.com/blog/really-find-headache-specialist/
https://migraine.com/living-migraine/neurologist-vs-specialist
https://migraine.com/living-migraine/change-thoughts-new-careHave you had an opportunity to track your attacks? This is a great way to see what patterns/triggers/symptoms attacks may have and can be very useful for our doctors. Here is more information on this; https://migraine.com/blog/keeping-migraine-diary-basics
Getting Botox from a doctor who is a true expert is imperative!! I really can't stress this enough. Not every doctor who does Botox follows the migraine protocol which again, is imperative. Something else to consider is it can take three, four maybe more rounds of Botox before we see improvement. It took three rounds for me.
It's difficult to keep in mind migraine is a neurological disease we manage, not cure. If we can get a 50% reduction in attacks, that's a start!
I've given you a lot of information so I'll stop now so I don't' totally overwhelm you. Will you let me know what you think? If I can help in any other way, please let me know!!
Nancy Harris Bonk, Patient Leader/Moderator Migraine.com TeamBeen trying them for about 8 months. I typically have migraines half the month, been using imitrex on them. It works, but cardiovascular diseases runs in the family, and I’m hitting menopause. Topomax didn’t do much except give me side effects; propranolol didn’t help much with the headaches, though I quite like it for anxiety.
So first we tried the oral routes: nurtec address the acute migraine. It did give me two weeks of acid stomach & diarrhea… and also knocked out my migraines for several weeks after. Partial success, but won’t be trying it again. Ubrelvy was better at the acute migraine, almost comparable to imitrex, but with no obvious long term effects.
For the monoclonal injections, I’ve tried Ajovy & Emgality. Avoiding Aimovig for now, assuming it will be like the nurtec.
Both Ajovy & Emgality give me injection site reactions. The Ajovy is much worse: I have to take claritin and Benadryl for several days. I just injected on Thursday, and I’m currently sporting hives on my neck. Emgality, meanwhile, makes me lose hair at a distressing rate. Took me a while to prove it was the Emgality, not the propranolol.
