I've had migraines since 1992, when the only migraine specific relief was Migranal, years before Imitrex was available. My first experience with Botox was at my pain management doctor's office, during the very first month insurance companies would cover the treatment. Unfortunately, I didn't find any relief after undergoing two separate series of shots. A few years later a second doctor, specializing in pain management, tried twice and failed to produce any relief. Then, in preparation for having a nerve impingement surgery done by a plastic surgeon (absolutely the BEST relief I've found), I underwent several different pinpoint injections, including Botox, meant to last just a few days to test my nerve involvement. The Botox test left me with 3 days of horrible migraine pain. The surgery was a complete success. I rarely have pain in the area he addressed, but I still have pain in other areas of my head.
I'm now seeing a new neurologist who specializes in migraines, and the first thing she wanted me to do, even before my first appointment, was Botox. I've found that each doctor along the way has boasted of their own "special method" of application of Botox. However, once the medication is injected, if there is a negative response (like an allergy or migraine pain) you have to wait out the life cycle of the medication for relief. So far she's gone along with my refusal, but none of the new medicines we've tried have worked either.
I think I have to put Botox in with the countless other medications I've tried that haven't worked, especially given the long recovery time if it causes problems. However, there's always a little "but what if..." doubt that lives on, spurred by the overwhelming desire to find pain relief. It's kept me searching for 30 years.