I have had migraines for many years. I finally found a neurologist who prescribed Vyepti. After I started 300mg Vyepti, there was about a dramatic 50%-75% reduction in my migraines. Until I started Lexapro about a year ago. All of a sudden, my migraine frequency increased way beyond their baseline before starting Vyepti ... they tripled as compared to being on Vyepti without Lexapro.
People told me I had "broken through" the Vyepti. Well, in January, I decided to taper off Lexapro. Even in the first few weeks there was improvement and I haven't even had one in about a month now. I think it's still too soon to draw a definitive conclusion - maybe at least another 1-4 months till I'm totally convinced. But it sure seems like the Lexapro was the culprit.
Has anyone else encountered this. Are there any SSRIs or SNRIs that don't tend to increase migraine frequency? I sure felt better when I was on Lexapro and would like to try to find another antidepressant. But given the choice, I'll stay off one if it makes this much difference.