Hi rhondajb1,
Thanks for your question and being here with us! I also have RLS and periodic limb movement and have found staying asleep to be an issue. I do know Benadryl and other medications can make my RLS worse. These include some antihistamines, medications that help with nausea and others. So it's entirely possible the cocktail they gave you in the ER could have triggered RLS.
I've recently become a certified Cannabis patient in NYS and have found this to be VERY helpful in treating my RLS and periodic limb movement disorder.
If this continues or becomes more problematic, please contact your doctor and let him know what is going on.
I hope this helps,
Nancy