I am a 56 year old male - migraines since 40 or so, on average 20-25 days per month, no obvious triggers except altitude (skiing in Colorado) and exertion (running sometimes intensifies a budding migraine). Sumatriptan works for me but I get only 10 pills a month so I often cut them up as 1/2 or even 1/3 will suppress the migraine, otherwise I run out. I take Feverfew and Magnesium daily - Feverfew seems to help a tiny bit.
I have taken amitriptyline low dose (no help), topiramate (nothing), propanolol (nothing) and a litany of other meds with little success. Have experimented with ice and heat - very modest temporary relief of pain.
So here's the main point - I tried Aimovig - first dose no migraines for the entire month (haven't had that in past 10 years), but after that, waning effects to the point where I stopped it after 6 months and moved on to Nurtec as it is now approved as a preventative. After two months on Nurtec, no noticeable improvement - doesn't touch my active migraine and doesn't otherwise seem to reduce frequency or intensity.
Out of desperation during a really bad month and running out of Sumatriptan, I had one leftover dose of Aimovig (140 mg) and took it. So far, day 3, seems effective, at least for now.
Has anyone else had a similar reaction to Aimovig? Potent for first month, but then falls off.
I think Aimovig and Nurtec both work on CGRP receptors. I was considering trying Ajovy which, I believe, works on CGRP more directly. Since there's evidence for me that CGRP is involved with my migraines (Aimovig does seem to work, albeit temporarily) trying Ajovy seems like a logical next step.
Has anyone else jumped around like this, looking for the correct med? I suppose there are multiple types of migraines and finding the correct preventative med may be possible now with all of these options.
My doctor continues to push botox but I am trying to give the new meds a chance before going that route.